期刊
JOURNAL OF CLINICAL VIROLOGY PLUS
卷 2, 期 1, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jcvp.2022.100062
关键词
Adults; Coinfection; COVID-19; Human immunodeficiency virus; Severe respiratory syndrome coronavirus 2
资金
- Health and Medical Research Fund-Commissioned Research on the Novel Coronavirus Disease (COVID-19) from the Food and Health Bureau, Hong Kong SAR Government [COVID190107]
This study assessed viral RNA and cytokine profiles in HIV patients with SARS-CoV-2 infection in Hong Kong. The results showed that HIV patients had similar respiratory viral shedding compared to controls, but had lower levels of IL-10 and NT-proBNP.
Objectives: Little is known whether differences exist in virus shedding, immune and inflammatory response related to SARS-CoV-2 in people living with human immunodeficiency virus (PLWH). We assessed viral RNA and cytokine profiles of HIV and SARS-CoV-2 coinfection in Hong Kong. Methods: PLWH hospitalized with SARS-CoV-2 infection in Hong Kong were included, compared with age-matched and disease severity-matched SARS-CoV-2 infected controls (ratio of 1:5) from February 1st 2020 to July 31st 2020. SARS-CoV-2 infection was confirmed by public health laboratory and virus concentration was quantified by an in-house real-time reverse transcription-quantitative polymerase chain reaction. A panel of cytokines and chemokines were performed. Results: HIV patients had a similar respiratory shedding profile compared to controls. Duration of faecal shedding of patient A, B, C and D were at least 9, 10, 33, and 11 days, respectively. HIV patients had lower plasma levels of IL-10 and NT-pro-BNP. All 4 PLWH cases showed seroconversion to SARS-CoV-2 with anti-SARS-CoV-2 S antibodies detected in serum collected between day 18 and 30 after symptom onset. Conclusions: PLWH behaves similarly with HIV-negative controls in respiratory viral load, but with decrease in IL-10 and NT-proBNP. PLWH may have a lower risk of immunostimulatory effect due to lower IL-10.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据