期刊
NEW JOURNAL OF CHEMISTRY
卷 46, 期 24, 页码 11492-11501出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2nj01541b
关键词
-
资金
- Ministere de l'Enseignement Superieur
- Centre National de la Recherche Scientifique
Functionalized 1,3-enynes bearing an acetal moiety at the 2-position were prepared through Sonogashira reaction. The reaction showed excellent substrate tolerance and could be easily scaled up. This method has important application in the synthesis of a key intermediate for glucagon antagonist.
The preparation of functionalized 1,3-enynes bearing an acetal moiety at the 2-position has been studied through Sonogashira reaction of bromovinyl acetals with various alkyl- and aryl-substituted terminal alkynes. The palladium-catalyzed coupling reaction tolerated a wide substrate scope and a range of 2-acetal-1,3-enynes were obtained in up to 87% yield under mild conditions that could be transposed to multi-gram scale. This protocol has been applied to the preparation of a key intermediate in the synthesis of a glucagon antagonist.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据