Two-photon fluorescence imaging of the cerebral peroxynitrite stress in Alzheimer's disease

We designed and synthesized an oxindole-functionalized two-photon fluorescent probe based on a naphthalimide fluorophore, which enabled in situ visualization of the overwhelming peroxynitrite flux during amyloid-beta-induced neuronal ferroptosis and cerebral peroxynitrite stress in live mice with Alzheimer's disease.

Automated summary

In this study, a novel fluorescent probe was designed and synthesized, allowing the visualization of the crucial role of peroxynitrite in Alzheimer's disease through in vivo experiments in mice.