A cobalt covalent organic framework: a dual-functional atomic-level catalyst for visible-light-driven C-H annulation of amides with alkynes

The merger of transition-metal catalysis and photoredox catalysis enables a balance between elegant chemical transformation and the rational use of light energy. Previously, it was always accomplished with the two types of homogeneous catalysts: transition-metal catalysts and photoredox catalysts. Herein, we report a synthesis of a dual-functional cobalt covalent organic framework (CoCOF-SYNU-1) for visible-light-driven C-H annulation of amides with alkynes. An atomic-level cobalt center ensures the occurrence of powerful chelation with amides and subsequent precise C-H activation, while the photoactive covalent organic framework is responsible for absorbing visible light to accelerate the catalytic cycle. In the presence of CoCOF-SYNU-1, visible-light-driven regioselective [4 + 2] C-H annulation proceeded smoothly, delivering a wide range of isoquinolin-1(2H)-one derivatives with high efficiency. Significantly, due to the inherent heterogeneous nature and good stability of CoCOF-SYNU-1, the reaction exhibits excellent catalyst recyclability and practicability.

Automated summary

The merger of transition-metal catalysis and photoredox catalysis has achieved a balance between chemical transformation and the rational use of light energy. A dual-functional cobalt covalent organic framework (CoCOF-SYNU-1) was synthesized for visible-light-driven C-H annulation of amides with alkynes. The reaction showed excellent catalyst recyclability and practicability.