期刊
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
卷 33, 期 5, 页码 -出版社
SPRINGER
DOI: 10.1007/s10856-022-06663-6
关键词
-
资金
- National Natural Science Foundation of China [30973003, 30901993]
- Administration of TCM of Jiangsu Province, China [LZ11093]
This study evaluates the feasibility and cardio-protective effects of a biocompatible silicon-built restraint device (ASD) in a rat model of heart failure. The results show that the ASD device is safe and effective in attenuating ventricular remodeling and improving heart function. Furthermore, ASD treatment reduces myocardial fibrosis, indicating significant therapeutic effects.
This study aims to evaluate the feasibility and cardio-protective effects of biocompatible silicon-built restraint device (ASD) in the rat's heart failure (HF) model. The performance and compliance characteristics of the ASD device were assessed in vitro by adopting a pneumatic drive and ball burst test. Sprague-Dawley (SD) rats were divided into four groups (n = 6); control, HF, HF + CSD, and HF ASD groups, respectively. Heart failure was developed by left anterior descending (LAD) coronary artery ligation in all groups except the control group. The ASD and CSD devices were implanted in the heart of HF + ASD and HF + CSD groups, respectively. The ASD's functional and expansion ability was found to be safe and suitable for attenuating ventricular remodeling. ASD-treated rats showed normal heart rhythm, demonstrated by smooth -ST and asymmetrical T-wave. At the same time, hemodynamic parameters of the HF ASD group improved systolic and diastolic functions, reducing ventricular wall stress, which indicated reverse remodeling. The BNP values were reduced in the HF + ASD group, which confirmed ASD feasibility and reversed remodeling at a molecular level. Furthermore, the HF + ASD group with no fibrosis suggests that ASD has significant curative effects on the heart muscles. In conclusion, ASD was found to be a promising restraint therapy than the previously standard restraint therapies. [GRAPHICS] .
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据