期刊
CHEMICAL SOCIETY REVIEWS
卷 51, 期 10, 页码 4175-4198出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cs01165k
关键词
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资金
- National Natural Science Foundation of China [52173132]
- 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University
- Fundamental Research Funds for Central Universities
Polyphenolic materials are fascinating and versatile bioinspired materials that can delicately regulate cell activities through both cell-material contact-dependent and contact-independent interactions. Comprehensive understanding of the relationship between material properties and desired biomedical applications at the cellular and molecular level can accelerate the translation of polyphenolic platforms from the lab to clinic.
Polyphenolic materials are a class of fascinating and versatile bioinspired materials for biointerfacial engineering. In particular, due to the presence of active chemical groups, a series of unique physicochemical properties become accessible and tunable of the as-prepared polyphenolic platforms, which could delicately regulate the cell activities via cell-material contact-dependent interactions. More interestingly, polyphenols could also affect the cell behaviors via cell-material contact-independent manner, which arise due to their intrinsically functional characteristics (e.g., antioxidant and photothermal behaviors). As such, a comprehensive understanding on the relationship between material properties and desired biomedical applications, as well as the underlying mechanism at the cellular and molecular level would provide material design principles and accelerate the lab-to-clinic translation of polyphenolic platforms. In this review, we firstly give a brief overview of cell hallmarks governed by surrounding cues, followed by the introduction of polyphenolic material engineering strategies. Subsequently, a detailed discussion on cell-polyphenols contact-dependent interfacial interaction and contact-independent interaction was also carefully provided. Lastly, their biomedical applications were elaborated. We believe that this review could provide guidances for the rational material design of multifunctional polyphenols and extend their application window.
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