期刊
CHEMICAL COMMUNICATIONS
卷 58, 期 43, 页码 6288-6291出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc01168a
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资金
- JNCASR
- DST, India
- DST
- UGC
- CEFPRA [IFCPAR/CEFIPRA-62T10-3]
A series of 2,2'-bipyridine derivatives with structurally unique biomolecular auxiliaries were synthesized and found to effectively ameliorate amyloid toxicity and oxidative stress observed in Alzheimer's disease (AD).
A series of 2,2 '-bipyridine derivatives appended with structurally unique biomolecular auxiliaries were synthesized and investigated for their ability to ameliorate multifaceted amyloid toxicity. Our results highlight the roles of the metal-chelating bipyridine core and functional auxiliaries in effectively modulating metal-independent and -dependent amyloid toxicity, and oxidative stress observed in Alzheimer's disease (AD).
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