Antiplatelet therapy after percutaneous coronary intervention

Antiplatelet therapy is key to reducing local thrombotic complications and systemic ischaemic events among patients undergoing percutaneous coronary interventions (PCI), but it is inevitably associated with increased bleeding. The continuous refinement in stent technologies, together with the high incidence of ischaemic recurrences after PCI and the understanding of prognostic implications associated with bleeding, have led to a substantial evolution in antiplatelet treatment regimens over the past decades. Numerous investigations have been conducted to better stratify patients undergoing PCI according to their ischaemic and bleeding risks and to implement antithrombotic regimens accordingly. Evidence from these investigations have resulted in a number of antithrombotic treatment options as recommended by recent guidelines. In this State-of-the-Art review we provide the rationale, summarise the evidence, and discuss current and future directions of antiplatelet treatment regimens after PCI.

Automated summary

Antiplatelet therapy is crucial for reducing thrombotic complications and ischemic events in patients undergoing percutaneous coronary interventions (PCI), but it is also associated with increased risk of bleeding. Advances in stent technologies and understanding of bleeding risks have led to the development of personalized antiplatelet treatment regimens. Recent research and guidelines have provided several options for antiplatelet therapy after PCI.