Transition-metal-free regioselective and stereoselective C(sp2)-C(sp3) coupling of enamides with ethers or alkanes via photoredox-catalyzed cross-dehydrogenative coupling reactions

A generally applicable and robust regio- and stereoselective cross-dehydrogenative-coupling of enamides with ethers or alkanes via transition-metal-free photoredox-catalysis under environmentally benign and atom economic conditions is demonstrated. The visible-light-induced transformations proceed smoothly with the aid of non-expensive and non-poisonous organic dyes, forging geometrically defined and synthetically paramount beta-alkylated enamides with broad substituent diversity and functional group compatibility.

Automated summary

This study demonstrates a generally applicable and robust regio- and stereoselective cross-dehydrogenative coupling of enamides with ethers or alkanes via transition-metal-free photoredox catalysis. The visible-light-induced transformations proceed smoothly with the aid of non-expensive and non-poisonous organic dyes, resulting in geometrically defined and synthetically important beta-alkylated enamides with broad substituent diversity and functional group compatibility.