期刊
CHINESE JOURNAL OF ORGANIC CHEMISTRY
卷 42, 期 4, 页码 945-964出版社
SCIENCE PRESS
DOI: 10.6023/cjoc202110008
关键词
benzo[b]furan; cross-coupling reaction; cyclization reaction; metal catalyst; catalyst free; research progress
资金
- Graduate Student Innovation Funds of Southwest Minzu University [CX2020SZ18]
- Sichuan Provincial Department of Science and Technology Support Program [2015NZ0033]
The benzo[b]furan structure is commonly found in natural products and bioactive compounds. Its derivatives have shown various pharmacological activities, such as antiviral, anticancer, insecticidal, anti-inflammatory, analgesic, and antioxidant properties. In recent years, the synthesis of substituted benzo[b]furan derivatives using cyclization or coupling reactions under transition metal catalysis or catalyst-free conditions has gained significant attention.
Benzo[b]furan structure is found in many natural products and bioactive compounds. Benzo[b]furan derivatives have attracted the attention of pharmaceutical chemists because of their antiviral, anticancer, insecticidal and anti inflammatory, analgesic and antioxidant activities. At present, many effective synthetic methods have been reported and become one of the hot topics of organic synthesis research in recent years. The research progress in the synthesis of substituted benzo[b]furan derivatives by cyclization or coupling reaction under the conditions of transition metal catalysis and catalysts free in recent ten years is reviewed.
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