Construction of Fluoro-containing Heterocycles Mediated by Free Radicals

Fluoro-containing heterocyclics play an important role in many fields, such as organic chemistry, pharmaceutical chemistry and material science due to their excellent physical and chemical properties. However, there are few natural fluoro-containing heterocyclics in nature, so it is particularly important to develop efficient synthesis methods of fluoro-containing heterocyclics. With the rapid development of transition metal catalyzed, photocatalyzed and electrocatalyzed radical reactions, radical chemistry has made a breakthrough in the field of synthesis and stimulated the interest of organic chemists in constructing fluoro-containing heterocyclics by using radical chemistry. In this paper, monofluoroallcylation, difluoroalkylation, trifluoromethylation, trilluoroalkoxy/sulfuriselenylation, perfluoroalkylation of unsaturated hydrocarbons and direct C-H fluoroalkylation of heterocycles are classified, and the construction of fluorine-containing side chain heterocycles mediated by free radicals is discussed from the aspects of transition metal catalysis, photocatalysis and electrocatalysis.

Automated summary

Fluoro-containing heterocyclics have excellent physical and chemical properties, making them important in various fields. Developing efficient synthesis methods is crucial due to the scarcity of natural fluoro-containing heterocyclics. Radical chemistry has made breakthroughs in synthesis, particularly with the use of transition metal catalysis, photocatalysis, and electrocatalysis. This paper focuses on the classification and construction of fluorine-containing side chain heterocycles using free radicals.