☆ 4.7 Article

Role of the cGAS-STING Pathway in Aging-related Endothelial Dysfunction

AGING AND DISEASE (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Cell Biology

The miR-214-3p/c-Ski axis modulates endothelial-mesenchymal transition in human coronary artery endothelial cells in vitro and in mice model in vivo

Juan Wang et al.

Summary: Cardiovascular disease (CVD) is a high-fatality non-communicable disease worldwide. Hypertension, a common cardiovascular condition, is a significant risk factor for heart failure development due to the activation of the renin-angiotensin system (RAS) and subsequent myocardial fibrosis (MF). This study finds that the miR-214-3p/c-Ski axis regulates angiotensin II (Ang II)-induced endothelial to mesenchymal transition (End-MT) in HCAECs and cardiac hypertrophy and fibrosis in a mouse model.

HUMAN CELL (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Honokiol improves endothelial function in type 2 diabetic rats via alleviating oxidative stress and insulin resistance

An He et al.

Summary: This study aimed to investigate the effect of Honokiol (HKL) on endothelial dysfunction in type 2 diabetic rats and its potential mechanism. The results demonstrated that HKL could ameliorate endothelial dysfunction, alleviate insulin resistance, and reduce oxidative stress, suggesting that HKL may be a promising treatment option for diabetes.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

cGAS-STING pathway: post-translational modifications and functions in sterile inflammatory diseases

Ze Hong et al.

Summary: Cytoplasmic microbial and host aberrant DNAs trigger host immune responses through the cGAS-STING pathway. This pathway's dysregulation is associated with autoimmune diseases, sterile inflammation, and cancers. This review summarizes the regulation of cGAS and STING, cell-specific activation, and their role in sterile inflammatory diseases, while discussing future directions and clinical applications.

FEBS JOURNAL (2022)

添加到收藏夹

Article Immunology

SIRT3-AMPK signaling pathway as a protective target in endothelial dysfunction of early sepsis

Huilin Yu et al.

Summary: This study found that the SIRT3-AMPK signaling pathway plays an important role in inhibiting vascular inflammation and endothelial dysfunction during early sepsis. Activation of AMPK can reverse the reduction of eNOS expression, prevent endothelial dysfunction, and improve survival. Inhibition of AMPK has opposite effects.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

添加到收藏夹

Article Cell Biology

Tubeimoside I Ameliorates Myocardial Ischemia-Reperfusion Injury through SIRT3-Dependent Regulation of Oxidative Stress and Apoptosis

Dingyi Lv et al.

Summary: The study demonstrates that TBM can protect against MIRI through regulation of oxidative stress and apoptosis, and this effect is dependent on SIRT3. TBM may be a potential drug candidate for MIRI treatment.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

添加到收藏夹

Review Neurosciences

Signaling by cGAS-STING in Neurodegeneration, Neuroinflammation, and Aging

Bindu D. Paul et al.

Summary: Recognition of foreign or misplaced nucleic acids is crucial for immune system to detect pathogens. The cGAS-STING pathway plays a key role in this process, but excessive engagement may lead to neuroinflammation and disease progression.

TRENDS IN NEUROSCIENCES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Aging drives organ-specific alterations of the inflammatory microenvironment guided by immunomodulatory mediators in mice

Patrick Schaedel et al.

Summary: Aging is often accompanied by chronic systemic inflammation, referred to as inflammaging, which plays a major role in age-associated diseases. Research shows that different organs have organ-specific responses to inflammatory cytokines, chemokines, and lipid mediators, with varying levels of pro-inflammatory and pro-resolving mediators during the aging process.

FASEB JOURNAL (2021)

添加到收藏夹

Article Cell Biology

Protective Effect of Sirtuin 3 on CLP-Induced Endothelial Dysfunction of Early Sepsis by Inhibiting NF-κB and NLRP3 Signaling Pathways

Dingyi Lv et al.

Summary: This study demonstrates the critical role of SIRT3 in endothelial dysfunction in sepsis, with protective effects against vascular inflammation by inhibiting the activation of NF-kappa B and NLRP3 pathways, and maintaining the expression of endothelial nitric oxide synthase and endothelium-dependent relaxation function. These findings suggest a potential therapeutic target in vascular dysfunction and septic shock.

INFLAMMATION (2021)

添加到收藏夹

Article Immunology

Contribution of the NLRP3/IL-1β axis to impaired vasodilation in sepsis through facilitation of eNOS proteolysis and the protective role of melatonin

Shupeng Hu et al.

Summary: Endothelial dysfunction is a typical feature of sepsis, and the NLRP3/IL-1β axis may impair vasodilation by promoting eNOS proteolysis. Melatonin may protect against sepsis-induced endothelial relaxation dysfunction by inhibiting the NLRP3/IL-1β axis, suggesting its pharmacological potential in sepsis.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Olive leaf extract supplementation improves the vascular and metabolic alterations associated with aging in Wistar rats

Daniel Gonzalez-Hedstrom et al.

Summary: Olive leaf extract exerts anti-inflammatory and antioxidant effects in aged rats, attenuating vascular function alterations associated with aging.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Article Cell Biology

Inhibition of the cGAS-STING pathway ameliorates the premature senescence hallmarks of Ataxia-Telangiectasia brain organoids

Julio Aguado et al.

Summary: Ataxia-telangiectasia (A-T) is a genetic disorder caused by the lack of functional ATM kinase, leading to chronic inflammation and premature aging in the central nervous system. The cGAS-STING pathway is shown to play a crucial role in recognizing micronuclei and inducing senescence-associated secretory phenotype (SASP) in A-T cells and brain organoids, making it a novel therapeutic target for treating neuropathology in A-T patients.

AGING CELL (2021)

添加到收藏夹

Article Physiology

A cGAS-dependent response links DNA damage and senescence in alveolar epithelial cells: a potential drug target in IPF

Michael Schuliga et al.

Summary: The study found that cGAS expression is detected in fibrotic tissue from lungs of patients with idiopathic pulmonary fibrosis (IPF), and cGAS plays an important role in exacerbating AEC senescence. Pharmacological inhibition of cGAS can alleviate IPF-AEC senescence, suggesting cGAS as a potential therapeutic target for IPF.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

An Overview of NO Signaling Pathways in Aging

Ali Mohammad Pourbagher-Shahri et al.

Summary: This review highlights the crucial role of nitric oxide (NO) in cellular aging processes, discussing its mechanisms and effects in various systems and organs, as well as the decline in NO levels and bioavailability associated with aging. Additionally, potential therapeutic agents affecting NO signaling mechanisms in aging are also discussed.

MOLECULES (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies

Suowen Xu et al.

Summary: The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in maintaining multiorgan health and homeostasis. Dysfunction of the vascular endothelium is associated with various diseases and is implicated in severe coronavirus disease 2019. Therapeutic approaches targeting endothelial dysfunction may have potential for treatment of cardiovascular and many other diseases.

PHARMACOLOGICAL REVIEWS (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

cGAS-STING Signaling Pathway and Liver Disease: From Basic Research to Clinical Practice

Bangjie Chen et al.

Summary: The cGAS-STING signaling pathway plays a significant role in liver diseases, inhibiting HBV replication and associated with tumor immunity in HCC. Its activation provides new insights for understanding and treating liver diseases.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Review Cell Biology

The Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases

Zhilei Wang et al.

Summary: Inflammation is a protective response regulated by the host, with cGAS-STING pathway playing a crucial role in immune defense, viral infections, fatty liver, and cancer metastasis. The potential impact of this pathway in liver diseases has attracted widespread attention, with pharmacological agonists and antagonists offering new therapeutic possibilities. Understanding the mechanisms of cGAS-STING pathway may lead to the development of effective treatments for liver diseases.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Inflammatory Mechanisms Contributing to Endothelial Dysfunction

Panagiotis Theofilis et al.

Summary: Maintenance of endothelial cell integrity is crucial for human health, as dysfunction can lead to various diseases. Activated and injured endothelial cells release inflammatory mediators and enter a pro-thrombotic state, ultimately promoting atherosclerosis progression. Various pathways and mechanisms contribute to endothelial dysfunction, highlighting the complexity of this process.

BIOMEDICINES (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Autophagy inhibits the mesenchymal stem cell aging induced by D-galactose through ROS/JNK/p38 signalling

Dayong Zhang et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2020)

添加到收藏夹

Review Oncology

Cellular senescence and senescence-associated secretory phenotype via the cGAS-STING signaling pathway in cancer

Tze Mun Loo et al.

CANCER SCIENCE (2020)

添加到收藏夹

Article Cell Biology

Role of the Nucleotide-Binding Domain-Like Receptor Protein 3 Inflammasome in the Endothelial Dysfunction of Early Sepsis

Minghao Luo et al.

INFLAMMATION (2020)

添加到收藏夹

Article Medicine, General & Internal

Antiplatelet strategies in ageing patients with acute coronary syndromes

Peter R Sinnaeve et al.

LANCET (2020)

添加到收藏夹

Review Cell Biology

Molecular mechanisms and cellular functions of cGAS-STING signalling

Karl-Peter Hopfner et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

添加到收藏夹

Review Cell Biology

Mitochondrial ROS-Modulated mtDNA: A Potential Target for Cardiac Aging

Yue Quan et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

添加到收藏夹

Article Medicine, General & Internal

Mediterranean diet and endothelial function in patients with coronary heart disease: An analysis of the CORDIOPREV randomized controlled trial

Elena M. Yubero-Serrano et al.

PLOS MEDICINE (2020)

添加到收藏夹

Article Cell Biology

Moringa oleifera Seeds Improve Aging-Related Endothelial Dysfunction in Wistar Rats

Joseph Iharinjaka Randriamboavonjy et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

SIRT6-mediated transcriptional suppression of MALAT1 is a key mechanism for endothelial to mesenchymal transition

Wei Qin et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2019)

添加到收藏夹

Article Medicine, Research & Experimental

Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure

Andras Iring et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Potential pitfalls in analyzing structural uncoupling of eNOS: aging is not associated with increased enzyme monomerization

Fumin Chang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2019)

添加到收藏夹

Article Immunology

Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability

Britney Johnson et al.

IMMUNITY (2018)

添加到收藏夹

Review Immunology

The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer

Tuo Li et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Related Disease

Anthony J. Donato et al.

CIRCULATION RESEARCH (2018)

添加到收藏夹

Review Cell Biology

Cellular senescence: Molecular mechanisms and pathogenicity

Wenqiang Wei et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

添加到收藏夹

Review Endocrinology & Metabolism

Inflammaging: a new immune-metabolic viewpoint for age-related diseases

Claudio Franceschi et al.

NATURE REVIEWS ENDOCRINOLOGY (2018)

添加到收藏夹

Review Pharmacology & Pharmacy

Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases

Jun Ren et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2018)

添加到收藏夹

Article Cell Biology

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

Selene Gluck et al.

NATURE CELL BIOLOGY (2017)

添加到收藏夹

Review Endocrinology & Metabolism

Inflammaging and 'Garb-aging'

Claudio Franceschi et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2017)

添加到收藏夹

Article Hematology

Endothelial Functions

Shigeo Godo et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2017)

添加到收藏夹

Review Cell Biology

Hypertension and aging

Thomas W. Buford

AGEING RESEARCH REVIEWS (2016)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Vascular endothelium - Gatekeeper of vessel health

Paul A. Cahill et al.

ATHEROSCLEROSIS (2016)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Pharmacological Strategies to Retard Cardiovascular Aging

Irene Alfaras et al.

CIRCULATION RESEARCH (2016)

添加到收藏夹

Review Oncology

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar et al.

ANNALS OF TRANSLATIONAL MEDICINE (2016)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Evolving Therapies for Myocardial Ischemia/Reperfusion Injury

Borja Ibáñez et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

Siqi Liu et al.

SCIENCE (2015)

添加到收藏夹

Article Geriatrics & Gerontology

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

Claudio Franceschi et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)

添加到收藏夹

Article Medicine, Research & Experimental

Linking endothelial dysfunction with endothelial cell activation

James K. Liao

JOURNAL OF CLINICAL INVESTIGATION (2013)

添加到收藏夹

Review Immunology

The broad-spectrum antiviral functions of IFIT and IFITM proteins

Michael S. Diamond et al.

NATURE REVIEWS IMMUNOLOGY (2013)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

The Intersection Between Aging and Cardiovascular Disease

Brian J. North et al.

CIRCULATION RESEARCH (2012)

添加到收藏夹

Article Physiology

Replicative Aging Induces Endothelial to Mesenchymal Transition in Human Aortic Endothelial Cells: Potential Role of Inflammation

Bradley S. Fleenor et al.

JOURNAL OF VASCULAR RESEARCH (2012)

添加到收藏夹

Editorial Material Hematology

Angiogenesis, stem cells, eNOS and inflammation - the many faces of vascular biology

Jozef Dulak et al.

THROMBOSIS AND HAEMOSTASIS (2012)

添加到收藏夹

Review Urology & Nephrology

Endothelial dysfunction

DH Endemann et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2004)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.