期刊
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
卷 20, 期 -, 页码 1743-1751出版社
ELSEVIER
DOI: 10.1016/j.csbj.2022.03.033
关键词
Systems biology; Networks; Transcriptional regulation; Forkhead transcription factors; Cell cycle; Metabolism
资金
- Systems Biology Grant of the University of Surrey
Transcription factors are essential for regulating the genomic landscape of cells, and the Forkhead (Fkh) transcription factors have been shown to play important roles in the regulation of organismal physiology and cell division. Genome-wide studies, including Chromatin ImmunoPrecipitation (ChIP) assays, have provided insights into the genomic landscape regulated by Forkheads in eukaryotes. These studies have revealed the involvement of Forkheads in the regulation of metabolic networks and temporal coordination of cell cycle dynamics.
Transcription factors are regulators of the cell's genomic landscape. By switching single genes or entire molecular pathways on or off, transcription factors modulate the precise timing of their activation. The Forkhead (Fkh) transcription factors are evolutionarily conserved to regulate organismal physiology and cell division. In addition to molecular biology and biochemical efforts, genome-wide studies have been conducted to characterize the genomic landscape potentially regulated by Forkheads in eukaryotes. Here, we discuss and interpret findings reported in six genome-wide Chromatin ImmunoPrecipitation (ChIP) studies, with a particular focus on ChIP-chip and ChIP-exo. We highlight their power and challenges to address Forkhead-mediated regulation of the cellular landscape in budding yeast. Expression changes of the targets identified in the binding assays are investigated by taking expression data for Forkhead deletion and overexpression into account. Forkheads are revealed as regulators of the metabolic network through which cell cycle dynamics may be temporally coordinated further, in addition to their well-known role as regulators of the gene cluster responsible for cell division. (c) 2022 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/).
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