期刊
ADVANCED THERAPEUTICS
卷 5, 期 9, 页码 -出版社
WILEY
DOI: 10.1002/adtp.202200044
关键词
cancer therapy; triggered drug release; hydrogen sulfide; nanocarrier; self assembly; three-legged molecule
资金
- National Natural Science Foundation of China [81803469]
This study develops a H2S-responsive nanocarrier based on self-assembly, which can be used for controlled drug release in cancer therapy. The results show that the nanocarrier exhibits efficient H2S-responsive drug release in colon cancer cells and effectively inhibits tumor growth in animal models.
Hydrogen sulfide (H2S), a gaseous signaling molecule, is excessively produced in disease lesions like lung tumors and colorectal tumors. H2S is used as a trigger for stimuli-responsive drug delivery in cancer therapies, which enables controlled release of chemotherapeutics and improves their biocompatibility and efficacy. Herein, a H2S-responsive small-molecule nanocarrier is developed based on the self-assembly of a trigonal molecule, tris(azido benzyl)-tri(2-aminoethyl) amine (ATAEA). ATAEA with three H2S-responsive azido benzyl groups can self-assemble into nanocarriers (ATNPs) and encapsulate hydrophobic doxorubicin (DOX) to form drug-loaded nanoparticles (DOX/ATNPs). H2S induces the reduction of azido benzyl group and 1,6-elimination, which results in the dissociation of the ATAEA molecules and the nanoparticles. In HCT116 colon cancer cells, efficient H2S-responsive DOX release from DOX/ATNPs is observed. In vivo administration of DOX/ATNPs in colon tumor-bearing mice leads to higher drug accumulation in tumors and evident tumor growth inhibition, in comparison with non-responsive nanoparticles. This work provides a new strategy to develop H2S-responsive drug delivery systems for precise drug delivery to H2S-enriched disease lesions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据