期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 20, 期 21, 页码 4342-4351出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ob00546h
关键词
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资金
- Japan Society for Promotion Sciences (JSPS) [19K07016]
- KOSE Cosmetology Research Foundation
- Grants-in-Aid for Scientific Research [19K07016] Funding Source: KAKEN
In this study, emissive aminoquinoline derivatives (TFMAQ) containing alkylmorpholine and arylmorpholine groups were investigated for their photophysical properties, acid-responsiveness, and organelle targeting. Surprisingly, the TFMAQ derivatives with ethylmorpholine groups showed limited accumulation in lysosomes, which are known to favor alkylmorpholine group accumulation, and instead preferred accumulation in lipid droplets. These findings have significant implications for the development of organelle/tissue specific dyes for cell imaging and diagnosis.
Herein, we report emissive aminoquinoline derivatives (TFMAQ) containing alkylmorpholine and arylmorpholine groups and their photophysical properties, acid-responsiveness, and organelle targeting. The alkylmorpholine group is well-known to favour accumulation in lysosomes and be acid-responsive, but, counterintuitively, the TFMAQ derivatives containing ethylmorpholine groups showed limited accumulation in lysosomes and, instead, preferential accumulation in lipid droplets. The findings reported here will aid the development of organelle/tissue specific dyes for cell imaging and diagnosis.
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