期刊
CHINESE JOURNAL OF ORGANIC CHEMISTRY
卷 42, 期 3, 页码 896-900出版社
SCIENCE PRESS
DOI: 10.6023/cjoc202109021
关键词
Lumnitzera littorea; Penicillium sclerotiorum; secondary metabolite; furan derivative; inhibitory activity against alpha-glucosidase
资金
- National Natural Science Foundation of China [41866005, 22177023]
- Key Science and Technology Program of Hainan Province [ZDKJ202008]
- Innovative Research Projects of Postgraduates in Hainan Universities [Hys2020-307]
Two new furan derivatives and six known steroid compounds were isolated from Penicillium sclerotiorum HLL 113. Some of these compounds showed significant alpha-glucosidase inhibitory activity.
Two new furan derivatives, (2S,3S,5S)-2-(2-hydroxyethyl)-3-hydroxy-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran (1) and (2S,3S,5S)-2-allyl-3-hydroxy-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran (2), together with six known steroid compounds were isolated from Penicillium sclerotiorum HLL 113. 6,9-Epoxy-ergosta-7,22-dien-3-ol (5) was isolated from the genus Penicillium for the first tune. Their structures were elucidated on the basis of extensive spectroscopic methods. The test results of alpha-glucosidase inhibitory activity showed that (22E,4R)-ergosta-7,9(11),22-triene-3 beta,5 alpha,6 beta-triol (7) and derrisisoflavone K (8) have significant inhibitory activity.
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