Pd-Catalyzed Isomerization of Alkenes

Starting from commercially available simple olefms, alkene isomerization could realize the efficient construction of multi-substituted alkenes, which might be difficult to access with other synthetic methods, in an atom-economic manner via the stereoselective or positional-selective modulation of the carbon-carbon double bonds. The palladium catalyzed stereoselective (ZIE) and the positional selective isomerization reactions of alkenes are summarized. The mechanistic perspectives, and their synthetic applications in the synthesis of drug molecules and natural products are discussed in detail.

Automated summary

This article summarizes the methods of alkene isomerization, which can efficiently construct multi-substituted alkenes via the stereoselective or positional-selective modulation of carbon-carbon double bonds. These methods have important applications in the synthesis of drug molecules and natural products.