期刊
FRONTIERS IN GENETICS
卷 7, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2016.00169
关键词
retinal ganglion cells; gene regulatory networks; transcription factors; recombinant inbred strain; subtyp
资金
- DoD CDMRP from the USA Army Medical Research & Materiel Command and the Telemedicine and Advanced Technology [W81XWH1210255]
- NIH [R01EY017841]
- Vision Core Grant [P30EY006360]
- Unrestricted Funds and a Stein Innovation Award from Research to Prevent Blindness
- [T32EY007092-30]
- U.S. Department of Defense (DOD) [W81XWH1210255] Funding Source: U.S. Department of Defense (DOD)
Retinal ganglion cells (RGCs) are the output neuron of the eye, transmitting visual information from the retina through the optic nerve to the brain. The importance of RGCs for vision is demonstrated in blinding diseases where RGCs are lost, such as in glaucoma or after optic nerve injury. In the present study, we hypothesize that normal RGC function is transcriptionally regulated. To test our hypothesis, we examine large retinal expression microarray datasets from recombinant inbred mouse strains in GeneNetwork and define transcriptional networks of RGCs and their subtypes. Two major and functionally distinct transcriptional networks centering around Thy1 and Tubb3 (Class III beta-tubulin) were identified. Each network is independently regulated and modulated by unique genomic loci. Meta-analysis of publically available data confirms that RGC subtypes are differentially susceptible to death, with alpha-RGCs and intrinsically photosensitive RGCs (ipRGCs) being less sensitive to cell death than other RGC subtypes in a mouse model of glaucoma.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据