期刊
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
卷 3, 期 10, 页码 812-818出版社
WILEY-BLACKWELL
DOI: 10.1002/acn3.338
关键词
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资金
- Scottish Government's Chief Scientists Office, Government of Scotland [ETM/315, RA2647]
- Michael J Fox foundation [R43828]
- Department of Health
- Scottish Home Office Department of Health [R43401]
- Medical Research Council [G1000681]
- MRC [G1000691, G0600953, MR/L022656/1, G0900580, G0901945] Funding Source: UKRI
- Chief Scientist Office [ETM/315] Funding Source: researchfish
- Medical Research Council [MR/L022656/1, G0900580, G0901945, G0600953, G1000691] Funding Source: researchfish
- Parkinson's UK [J-0901, J-1403] Funding Source: researchfish
We have developed a novel real-time quaking-induced conversion RT-QuIC-based assay to detect alpha-synuclein aggregation in brain and cerebrospinal fluid from dementia with Lewy bodies and Parkinson's disease patients. This assay can detect alpha-synuclein aggregation in Dementia with Lewy bodies and Parkinson's disease cerebrospinal fluid with sensitivities of 92% and 95%, respectively, and with an overall specificity of 100% when compared to Alzheimer and control cerebrospinal fluid. Patients with neuropathologically confirmed tauopathies (progressive supranuclear palsy; corticobasal degeneration) gave negative results. These results suggest that RT-QuiC analysis of cerebrospinal fluid is potentially useful for the early clinical assessment of patients with alpha-synucleinopathies.
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