3.8 Article

On the Development of Reagent-free Conductive Nanocomposite Systems for the Modification of Printed Electrodes When Producing Glucose Biosensors

期刊

NANOBIOTECHNOLOGY REPORTS
卷 17, 期 1, 页码 106-117

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PLEIADES PUBLISHING INC
DOI: 10.1134/S2635167622010025

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  1. Ministry of Science and Higher Education of the Russian Federation [FEWG-2020-0008]

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The possibility of using redox-active polymers based on bovine serum albumin and chitosan covalently linked to neutral red, thionine, and ferrocene mediators, and containing carbon nanotubes for glucose-oxidase immobilization is investigated. The systems containing a redox-active polymer based on BSA modified with a ferrocene mediator are found to be the most promising. Biosensors formed using nanocomposite matrices have a high sensitivity and high correlation with the results of determining the glucose content in human blood by the standard method.
The possibility of using redox-active polymers based on bovine serum albumin (BSA) and chitosan covalently linked to neutral red, thionine, and ferrocene mediators, and containing carbon nanotubes (CNTs) for glucose-oxidase immobilization is investigated. The structure of the obtained polymers is studied by infrared (IR) spectroscopy, spectrophotometry, atomic-absorption spectroscopy, and scanning electron microscopy. Using the method of cyclic voltammetry, the electrochemical characteristics of the studied conductive nanocomposite systems are found, namely, a heterogeneous rate constant of electron transfer and a rate constant of interaction with glucose oxidase. The systems containing a redox-active polymer based on BSA modified with a ferrocene mediator turn out to be the most promising. Biosensors formed using nanocomposite matrices have a high sensitivity with a lower limit of determined glucose concentrations of 0.1 mM and are characterized by a high correlation (R (2) = 0.9827) with the results of determining the glucose content in human blood by the standard method.

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