期刊
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN
卷 80, 期 2, 页码 92-102出版社
SOC SYNTHETIC ORGANIC CHEM JPN
关键词
amine catalyst; phenylcyclopropane-based chiral amine; ketimine; asymmetric reaction; Mannich reaction; conjugate addition
Binaphthyl-based amine catalysts exhibit unique reactivity and stereoselectivity in asymmetric reactions, but are rarely used due to their synthetic inefficiency. Chiral secondary amine catalysts based on a phenylcyclopropane scaffold have been developed and show high catalytic activity in several asymmetric reactions.
Chiral amine catalysts are widely utilized in various asymmetric reactions. Among them, binaphthyl-based secondary amine catalysts show unique reactivity and unusual stereoselectivity in comparison with frequently used L-proline and its derivatives. In spite of their utility, however, asymmetric reactions employing binaphthyl-based amines are rare because of their synthetic inefficiency. In this context, we have developed chiral secondary amine catalysts based on a phenylcyclopropane scaffold as a novel chiral motif. Newly synthesized amine catalysts function as effective catalysts for several asymmetric reactions. In addition, the phenylcyclopropane-based amino sulfonamide was found to be an effective catalyst for the syn-selective Mannich reaction and conjugate addition with alkynyl Z-ketimines.
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