期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 18, 期 7, 页码 3019-3033出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.72534
关键词
tumor heterogeneity; tumor microenvironment; drug resistance
资金
- University of Macau [CPG2021-00021-FHS]
- Science and Technology Development Fund, Macau SAR [0011/2019/AKP]
Tumor heterogeneity is a major cause of drug resistance and affects drug efficacy by shaping the tumor microenvironment and therapeutic targets. Understanding the impact of tumor heterogeneity on drug resistance is important for cancer treatment and patient prognosis.
Tumor heterogeneity is one of the hallmarks of cancer and a challenge in the field of oncology. Tumor heterogeneity is the main cause of drug resistance, leading to therapeutic failure. Mechanically, tumor heterogeneity either directly affects therapeutic targets or shapes the tumor microenvironment (TME) by defining transcriptomic and phenotypic profiles to influence drug resistance. Tumor heterogeneity evolves spatially and temporally during tumor development, leading to the constant reprogramming of the TME. Advances in molecular profiling technologies and precision oncology platforms have allowed us to uncover the impact of tumor heterogeneity on drug resistance in the context of the TME. In this review, we focus on the processes during which genomic mutations drive tumor heterogeneity and the mechanisms through which tumor heterogeneity reprograms the TME to affect drug resistance and patient prognosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据