4.7 Article

Iodine(III)-promoted regioselective and efficient synthesis of β-triazolyl BODIPYs for the selective recognition of nickel ions and bovine serum albumin

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DALTON TRANSACTIONS
卷 51, 期 21, 页码 8169-8176

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ROYAL SOC CHEMISTRY
DOI: 10.1039/d2dt00946c

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  1. DST, New Delhi [EMR/2017/004118]
  2. UGC, New Delhi
  3. BITS Pilani

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This study efficiently synthesized various beta-triazolyl tethered BODIPYs using a one-pot protocol. The prepared compounds exhibited red-shifted absorption bands and showed selective recognition of Ni2+ and enhanced fluorescence upon interaction with bovine serum albumin. The results demonstrate the potential applications of these beta-triazolyl BODIPYs in sensing and imaging.
Various beta-triazolyl tethered BODIPYs were efficiently prepared in a sequential one-pot protocol involving the initial reaction of BODIPY with iodobenzene diacetate (IBD) and sodium azide to in situ generate BODIPY azides followed by a copper-catalyzed azide-alkyne cycloaddition reaction. Under the optimized reaction conditions, various beta-triazolyl BODIPYs 5a-i were successfully prepared in good yields and adequately characterized by using UV, NMR, mass spectral data and XRD analyses. The UV-Visible spectra of the prepared beta-triazolyl BODIPYs 5a-i showed intense absorption bands (514-545 nm) with a beta-44 nm red shift when compared with those of the parent BODIPY. The selective recognition of compound 5d towards Ni2+ ions (detection limit 0.26 nM) led to significant quenching in the fluorescence intensity over other selected bivalent metal ions. The complex formed between 5d and Ni2+ in a stoichiometry of 2 : 1 was found to have a binding constant of 7.5 x 10(5) M-1. The fluorescence of compound 5i gets enhanced gradually upon interaction with bovine serum albumin due to its selective and high binding affinity (1.25 x 10(5) M-1) with protein and a concomitant decrease in the total non-radiative decay rate.

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