The synthetic versatility of fluoroiodomethane: recent applications as monofluoromethylation platform

In recent years, fluoroiodomethane (CH2FI) has emerged as an easy-to-handle, non-ozone depleting agent and readily available platform for monofluoromethylation strategies. Recent applications in nucleophilic substitutions, lithiation reactions, transition-metal catalyzed transformations, radical processes, and F-18-radiolabelling chemistry showcase the potential of this reagent for the preparation of organofluorine compounds. In this minireview, we provide an update to the field covering the recent relevant literature on the use of CH2FI.

Automated summary

Fluoroiodomethane (CH2FI) has emerged as a convenient and readily available platform for monofluoromethylation strategies. Recent applications demonstrate its potential in the preparation of organofluorine compounds.