Rhodium(i)-catalyzed C-S bond formation via enantioselective carbenoid S-H insertion: catalytic asymmetric synthesis of α-thioesters

Asymmetric construction of C-S bonds through transition-metal catalysis is a challenging subject. By using chiral diene as the ligand, we have developed the first rhodium(i)-catalyzed asymmetric carbene insertion approach for C-S bond formation to access sulfur-substituted stereocenters under mild conditions, allowing the facile synthesis of a range of potentially valuable alpha-thioesters in high yields with moderate to good enantioselectivities.

Automated summary

In this study, the first rhodium(I)-catalyzed asymmetric carbene insertion approach for C-S bond formation was developed using a chiral diene as a ligand. This method allows the synthesis of a range of potentially valuable alpha-thioesters in high yields with moderate to good enantioselectivities under mild conditions.