期刊
JOURNAL OF TISSUE ENGINEERING
卷 13, 期 -, 页码 -出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/20417314221095997
关键词
Blood-brain-barrier; CNS; drug delivery; brain-on-chip; neurodegenerative disease
资金
- NIH [7R01AR072027]
- NSF [1905785, NSF 2025362]
- DOD [W81XWH2110274]
- University of Connecticut
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1905785] Funding Source: National Science Foundation
The blood-brain barrier is a specialized biological barrier that protects the brain from invasion. In vitro modeling of the blood-brain barrier has provided insights into transport mechanisms and disease effects, aiding in the development of treatments.
The blood-brain barrier (BBB) is the most specialized biological barrier in the body. This configuration of specialized cells protects the brain from invasion of molecules and particles through formation of tight junctions. To learn more about transport to the brain, in vitro modeling of the BBB is continuously advanced. The types of models and cells selected vary with the goal of each individual study, but the same validation methods, quantification of tight junctions, and permeability assays are often used. With Transwells and microfluidic devices, more information regarding formation of the BBB has been observed. Disease models have been developed to examine the effects on BBB integrity. The goal of modeling is not only to understand normal BBB physiology, but also to create treatments for diseases. This review will highlight several recent studies to show the diversity in model selection and the many applications of BBB models in in vitro research.
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