Synthesis, spectral characterization and antiproliferative activity of new organotin(IV) dithiocarbamate compounds on K562 cells

Four new organotin(IV) dithiocarbamate compounds with general formulae of PhnSn [S2CN(CH2CH2OCH2CH3)]4-n for compound 1 and 2; and PhnSn[S2CN(CH3)(CH2CH2C6H5)]4-n for compound 3 and 4 were successfully synthesized via in situ insertion method. These compounds namely, diphenyltin(IV)- [1] and triphenyltin(IV) N,N-bis(2-ethoxyethyl)dithiocarbamate [2], diphenyltin(IV)- [3] and triphenyltin(IV) N-methyl-Nphenethyldithiocarbamate [4] were each characterized with CHNS elemental analysis, FT-IR and NMR spectroscopies (1H, 13C and 119Sn). The compounds were then assessed for their cytotoxicity against K562 cells using 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazholium bromide (MTT) assay upon 24 h treatment. All compounds produced the essential IR absorption bands and displayed important NCS2 peak in 13C NMR spectroscopy. From the cytotoxicity studies using MTT assay, the compounds were shown to inhibit cell proliferation in K562 leukemic cells with IC50 values ranging from 1.48 to 4.52 ??M, and in the manners more cytotoxic compared to standard used imatinib.

Automated summary

Four new organotin(IV) dithiocarbamate compounds were synthesized via in situ insertion method and characterized. These compounds showed cytotoxicity against K562 cells.