期刊
POLYMER CHEMISTRY
卷 13, 期 22, 页码 3343-3357出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2py00330a
关键词
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资金
- Thailand Science Research and Innovation (TSRI) [R2565B062]
- European Union [871650]
- Program Management Unit for Human Resources & Institutional Development, Research and Innovation, Office of National Higher Education Science Research and Innovation Policy Council (NXPO), Thailand [B16F640001]
- Center of Excellence in Materials Science and Technology, Chiang Mai University
- Marie Curie Actions (MSCA) [871650] Funding Source: Marie Curie Actions (MSCA)
Bio-derived and biocompatible nanogels based on poly(lactic acid) (PLA) and silk sericin (SS) were synthesized and embedded within nanofibers for potential use in tissue regeneration. Higher crosslink densities resulted in smaller nanogel particles with reduced drug release accumulation.
Bio-derived and biocompatible nanogels based on poly(lactic acid) (PLA) and silk sericin (SS) have been synthesized for the first time. Low molecular weight PLA and SS were first modified using allyl glycidyl ether to create a PLA macromonomer and an SS multifunctional crosslinker (PLAM and SSC, respectively), as confirmed by NMR and FTIR spectroscopies. Nanogels were synthesized from PLAM/SSC and N ',N-methylene bisacrylamide (N ',N-mBAAm) as an additional bifunctional crosslinker via classical free-radical polymerization at systematically varied levels of additional crosslinking (0, 0.5, 1.0, 1.5 and 2.0 w/w% N ',N-mBAAm). Higher crosslink densities led to smaller nanogel particles with reduced accumulative drug release. Crosslinked PLAM/SSC nanogels at 0.5% N ',N-mBAAm with 400-500 nm diameter particles were shown to be non-toxic to the normal human skin fibroblast cell line (NHSF) and selected for incorporation within poly(lactide-co-glycolide) (PLGA) electrospun nanofibers. These embedded nanogel-PLGA nanofibers were non-toxic to the NHSF cell line and exhibited higher cell proliferation than pure PLGA nanofibers, due to their higher hydrophilicity induced by the PLAM/SSC nanogels. This work shows that our new crosslinked-PLAM/SSC nanogels have potential for use not only in the field of drug delivery but also for tissue regeneration by embedding them within nanofibers to create hybrid scaffolds.
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