4.8 Article

Brown adipose TRX2 deficiency activates mtDNA-NLRP3 to impair thermogenesis and protect against diet-induced insulin resistance

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Endocrinology & Metabolism

Relation of diet-induced thermogenesis to brown adipose tissue activity in healthy men

Rahel Catherina Loeliger et al.

Summary: Cold-induced thermogenesis (CIT) is related to BAT activity, while diet-induced thermogenesis (DIT) is not associated with BAT activity. The increase in EE after glucose intake is not linked to stimulated BAT activity. Therefore, in humans, DIT may not be a function of BAT.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2021)

Article Immunology

Mitophagy-mediated adipose inflammation contributes to type 2 diabetes with hepatic insulin resistance

Feng He et al.

Summary: By analyzing the transcriptome landscape in human adipocytes, this study revealed elevated mitochondrial ROS pathway and NF-KB signaling, as well as altered fatty acid metabolism in T2DM adipocytes. Mouse experiments showed that adipose-specific deletion of mitochondrial Trx2 led to excessive mitophagy, increased inflammation, and lipolysis in white adipose tissues. Treatment with ROS scavenger or NF-KB inhibitor improved metabolic disorders and T2DM progression in mice.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Review Cardiac & Cardiovascular Systems

Clinical review on triglycerides

Ulrich Laufs et al.

EUROPEAN HEART JOURNAL (2020)

Article Geriatrics & Gerontology

NLRP3 Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity

Fabiola Marin-Aguilar et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2020)

Review Gastroenterology & Hepatology

Regulation of intestinal lipid metabolism: current concepts and relevance to disease

Chih-Wei Ko et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

Article Biochemistry & Molecular Biology

Chronic cold exposure enhances glucose oxidation in brown adipose tissue

Zhichao Wang et al.

EMBO REPORTS (2020)

Article Endocrinology & Metabolism

Moderate SIRT1 overexpression protects against brown adipose tissue inflammation

Carmen Escalona-Garrido et al.

MOLECULAR METABOLISM (2020)

Review Immunology

Innate Immune Control of Adipose Tissue Homeostasis

Harry Kane et al.

TRENDS IN IMMUNOLOGY (2019)

Article Medicine, General & Internal

Abnormal brown adipose tissue mitochondrial structure and function in IL10 deficiency

Jose C. de-Lima-Junior et al.

EBIOMEDICINE (2019)

Review Endocrinology & Metabolism

Metabolic adaptation and maladaptation in adipose tissue

Edward T. Chouchani et al.

NATURE METABOLISM (2019)

Review Immunology

The NLRP3 inflammasome: molecular activation and regulation to therapeutics

Karen V. Swanson et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Review Endocrinology & Metabolism

An energetic view of stress: Focus on mitochondria

Martin Picard et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2018)

Article Endocrinology & Metabolism

Brown adipose tissue derived ANGPTL4 controls glucose and lipid metabolism and regulates thermogenesis

Abhishek K. Singh et al.

MOLECULAR METABOLISM (2018)

Article Biochemistry & Molecular Biology

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis

Joel S. Riley et al.

EMBO JOURNAL (2018)

Review Biochemistry & Molecular Biology

Brown adipocyte glucose metabolism: a heated subject

Mohammed K. Hankir et al.

EMBO REPORTS (2018)

Review Physiology

Mitochondria, Oxidative Stress and Innate Immunity

Yuxin Chen et al.

FRONTIERS IN PHYSIOLOGY (2018)

Article Medicine, Research & Experimental

Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis

Binod Aryal et al.

JCI INSIGHT (2018)

Article Multidisciplinary Sciences

DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway

Juli Bai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Anatomy & Morphology

Thermogenesis, fatty acid synthesis with oxidation, and inflammation in the brown adipose tissue of ob/ob (-/-) mice

Fabiane Ferreira Martins et al.

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER (2017)

Article Critical Care Medicine

Role for NLRP3 Inflammasome-mediated, IL-1β-Dependent Responses in Severe, Steroid-Resistant Asthma

Richard Y. Kim et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)

Article Biochemistry & Molecular Biology

Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis

Kiana Mahdaviani et al.

EMBO REPORTS (2017)

Article Biochemistry & Molecular Biology

UCP1 in adipose tissues: two steps to full browning

Anastasia V. Kalinovich et al.

BIOCHIMIE (2017)

Article Endocrinology & Metabolism

Fatty acid metabolism and the basis of brown adipose tissue function

Maria Calderon-Dominguez et al.

ADIPOCYTE (2016)

Review Medicine, Research & Experimental

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

Varman T. Samuel et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Cell Biology

Leptin Raises Defended Body Temperature without Activating Thermogenesis

Alexander W. Fischer et al.

CELL REPORTS (2016)

Article Multidisciplinary Sciences

p21Cip1 plays a critical role in the physiological adaptation to fasting through activation of PPARα

Elena Lopez-Guadamillas et al.

SCIENTIFIC REPORTS (2016)

Editorial Material Cell Biology

Evolution of Mitochondria as Signaling Organelles

Navdeep S. Chandel

CELL METABOLISM (2015)

Review Medicine, Research & Experimental

Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis

Labros Sidossis et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Multidisciplinary Sciences

Mitochondrial DNA stress primes the antiviral innate immune response

A. Phillip West et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Rebecca C. Coll et al.

NATURE MEDICINE (2015)

Article Biochemistry & Molecular Biology

Loss of FTO in adipose tissue decreases Angptl4 translation and alters triglyceride metabolism

Chao-Yung Wang et al.

SCIENCE SIGNALING (2015)

Review Biochemistry & Molecular Biology

Mitochondria: diversity in the regulation of the NLRP3 inflammasome

Prajwal Gurung et al.

TRENDS IN MOLECULAR MEDICINE (2015)

Article Biochemistry & Molecular Biology

Loss of FTO in adipose tissue decreases Angptl4 translation and alters triglyceride metabolism

Chao-Yung Wang et al.

SCIENCE SIGNALING (2015)

Review Cell Biology

Mitochondria: from cell death executioners to regulators of cell differentiation

Atsuko Kasahara et al.

TRENDS IN CELL BIOLOGY (2014)

Review Biochemistry & Molecular Biology

Recent advance in brown adipose physiology and its therapeutic potential

Yun-Hee Lee et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2014)

Article Biochemistry & Molecular Biology

Adipose-specific Lipoprotein Lipase Deficiency More Profoundly Affects Brown than White Fat Biology

Itsaso Garcia-Arcos et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Review Biochemistry & Molecular Biology

Brown and beige fat: development, function and therapeutic potential

Matthew Harms et al.

NATURE MEDICINE (2013)

Article Cell Biology

UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

Irina G. Shabalina et al.

CELL REPORTS (2013)

Article Biochemistry & Molecular Biology

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

Andriy Fedorenko et al.

Review Genetics & Heredity

A new, powerful player in lipoprotein metabolism: brown adipose tissue

Alexander Bartelt et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2012)

Article Biochemistry & Molecular Biology

Brown adipose tissue activity controls triglyceride clearance

Alexander Bartelt et al.

NATURE MEDICINE (2011)

Review Immunology

Mitochondria in innate immune responses

A. Phillip West et al.

NATURE REVIEWS IMMUNOLOGY (2011)

Article Medicine, General & Internal

Brief Report: Functional Brown Adipose Tissue in Healthy Adults.

Kirsi A. Virtanen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Medicine, General & Internal

Cold-Activated Brown Adipose Tissue in Healthy Men

Wouter D. van Marken Lichtenbelt et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Medicine, General & Internal

Identification and Importance of Brown Adipose Tissue in Adult Humans.

Aaron M. Cypess et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Biochemistry & Molecular Biology

Inactivation of UCP1 and the glycerol phosphate cycle synergistically increases energy expenditure to resist diet-induced obesity

Rea Anunciado-Koza et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)