4.8 Article

HAX1-dependent control of mitochondrial proteostasis governs neutrophil granulocyte differentiation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Hematology

Heterozygous variants of CLPB are a cause of severe congenital neutropenia

Julia T. Warren et al.

Summary: Genetic analysis of patients with congenital neutropenia revealed an association between CLPB variants and the disease. CLPB variants obstruct the differentiation of granulocytes and increase apoptosis, contributing to the development of neutropenia. This study provides new insights into the diagnosis and treatment of congenital neutropenia.
Review Cell Biology

Quality control of the mitochondrial proteome

Jiyao Song et al.

Summary: Mitochondria contain a diverse array of proteins from two genomes and require synchronized gene expression for proper function. The mitochondrial proteome is highly adaptable and regulated by quality control systems to ensure cellular adaptation and functionality. Defects in mitochondrial protein quality control mechanisms can lead to proteotoxic insults and cell death, highlighting the critical importance of maintaining protein homeostasis in mitochondria.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Genetics & Heredity

Neutropenia and intellectual disability are hallmarks of biallelic and de novo CLPB deficiency

Saskia B. Wortmann et al.

Summary: This study investigated monoallelic CLPB variants in patients with a phenotype dominated by epilepsy, developmental issues, and 3-methylglutaconic aciduria. The results showed that these variants disrupt the refoldase and ATPase activity of CLPB, leading to a phenotypic spectrum centered around neurodevelopmental delay, seizures, and neutropenia, presumably mediated via HAX1.

GENETICS IN MEDICINE (2021)

Review Biochemistry & Molecular Biology

Coupling of import and assembly pathways in mitochondrial protein biogenesis

Alexander Grevel et al.

BIOLOGICAL CHEMISTRY (2020)

Review Biochemistry & Molecular Biology

Mitochondrial Proteases: Multifaceted Regulators of Mitochondrial Plasticity

Soni Deshwal et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 89 (2020)

Review Genetics & Heredity

Mitochondrial Protein Quality Control Mechanisms

Pooja Jadiya et al.

Article Cell Biology

A High-Density Human Mitochondrial Proximity Interaction Network

Hana Antonicka et al.

CELL METABOLISM (2020)

Review Microbiology

Cellular Functions and Mechanisms of Action of Small Heat Shock Proteins

Axel Mogk et al.

ANNUAL REVIEW OF MICROBIOLOGY, VOL 73 (2019)

Review Immunology

Biological Roles Of Neutrophil-Derived Granule Proteins and Cytokines

Marco Antonio Cassatella et al.

TRENDS IN IMMUNOLOGY (2019)

Article Multidisciplinary Sciences

Structural basis for substrate gripping and translocation by the ClpB AAA plus disaggregase

Alexandrea N. Rizo et al.

NATURE COMMUNICATIONS (2019)

Review Immunology

Metabolic Insight of Neutrophils in Health and Disease

Sachin Kumar et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Cell Biology

The multifaceted contributions of mitochondria to cellular metabolism

Jessica B. Spinelli et al.

NATURE CELL BIOLOGY (2018)

Article Multidisciplinary Sciences

Dynamic structural states of CIpB involved in its disaggregation function

Takayuki Uchihashi et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

Rebecca Freilich et al.

NATURE COMMUNICATIONS (2018)

Review Immunology

Kostmann's Disease and HCLS1-Associated Protein X-1 (HAX1)

Christoph Klein

JOURNAL OF CLINICAL IMMUNOLOGY (2017)

Article Endocrinology & Metabolism

A scoring system predicting the clinical course of CLPB defect based on the foetal and neonatal presentation of 31 patients

Ewa Pronicka et al.

JOURNAL OF INHERITED METABOLIC DISEASE (2017)

Article Multidisciplinary Sciences

Cytosolic proteostasis through importing of misfolded proteins into mitochondria

Linhao Ruan et al.

NATURE (2017)

Article Biochemistry & Molecular Biology

Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein

Ricarda Richter-Dennerlein et al.

Review Immunology

Granulopoiesis and granules of human neutrophils

Jack B. Cowland et al.

IMMUNOLOGICAL REVIEWS (2016)

Review Cell Biology

PARL: The mitochondrial rhomboid protease

Marco Spinazzi et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

A First Line of Stress Defense: Small Heat Shock Proteins and Their Function in Protein Homeostasis

Martin Haslbeck et al.

JOURNAL OF MOLECULAR BIOLOGY (2015)

Review Immunology

Neutrophil-derived cytokines: facts beyond expression

Cristina Tecchio et al.

FRONTIERS IN IMMUNOLOGY (2014)

Review Biochemistry & Molecular Biology

Mitochondrial protein import: Common principles and physiological networks

Jan Dudek et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)

Article Multidisciplinary Sciences

GABP transcription factor is required for development of chronic myelogenous leukemia via its control of PRKD2

Zhong-Fa Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Multiplex Genome Engineering Using CRISPR/Cas Systems

Le Cong et al.

SCIENCE (2013)

Article Biochemistry & Molecular Biology

Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development

Robert B. Hamanaka et al.

SCIENCE SIGNALING (2013)

Review Biochemistry & Molecular Biology

The role of PGC-1 coactivators in aging skeletal muscle and heart

Lloye M. Dillon et al.

IUBMB LIFE (2012)

Article Biochemical Research Methods

A Quantitative Spatial Proteomics Analysis of Proteome Turnover in Human Cells

Francois-Michel Boisvert et al.

MOLECULAR & CELLULAR PROTEOMICS (2012)

Article Cell Biology

Mitochondrial Complex III ROS Regulate Adipocyte Differentiation

Kathryn V. Tormos et al.

CELL METABOLISM (2011)

Article Biochemistry & Molecular Biology

UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells

Jin Zhang et al.

EMBO JOURNAL (2011)

Article Cell Biology

Quality Control of Mitochondrial Proteostasis

Michael J. Baker et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

Review Immunology

Neutrophils in the activation and regulation of innate and adaptive immunity

Alberto Mantovani et al.

NATURE REVIEWS IMMUNOLOGY (2011)

Article Oncology

A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth In vitro and In vivo

Kuzhuvelil B. Harikumar et al.

MOLECULAR CANCER THERAPEUTICS (2010)

Review Biochemistry & Molecular Biology

HAX-1: A multifunctional protein with emerging roles in human disease

Bengt Fadeel et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2009)

Review Biochemistry & Molecular Biology

Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology

Sergiy Kostenko et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2009)

Article Multidisciplinary Sciences

Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation

Edward Owusu-Ansah et al.

NATURE (2009)

Review Immunology

Neutrophil granule proteins tune monocytic cell function

Oliver Soehnlein et al.

TRENDS IN IMMUNOLOGY (2009)

Article Multidisciplinary Sciences

Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons

Jyh-Rong Chao et al.

NATURE (2008)

Article Genetics & Heredity

A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia

Maria Chiara Di Bernardo et al.

NATURE GENETICS (2008)

Article Genetics & Heredity

HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease)

Christoph Klein et al.

NATURE GENETICS (2007)

Review Biochemistry & Molecular Biology

Protein kinase D signaling

E Rozengurt et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)