期刊
CUREUS JOURNAL OF MEDICAL SCIENCE
卷 14, 期 4, 页码 -出版社
CUREUS INC
DOI: 10.7759/cureus.23828
关键词
magnetic resonance imaging; magnetic resonance angiography (mra); thrombotic coagulopathy; congenital abnormalities; embolic stroke of undetermined source
A 41-year-old man presented with recurrent micro thromboembolic strokes, which is unusual for his age, prompting further investigation. A rare plasminogen activator inhibitor-1 polymorphism associated with an increased risk of cerebrovascular thrombosis was discovered. This polymorphism has been less explored in recent medical literature and our case may stimulate future research.
Certain clinical scenarios should alert a physician to take a deeper look into causative pathological processes. This was evident in the case of a 41-year-old man who presented for recurrent micro thromboembolic strokes, which is atypical for the patient's age. Our desire to explain the pathological process led to the rare finding of a plasminogen activator inhibitor-1 polymorphism, which has been associated with an increased risk of cerebrovascular thrombosis. A defect in this pathway leads to the inhibition of the tissue plasminogen activator protein. This genetic polymorphism has relatively been unexplored in recent medical literature, and we are hoping that our case may inspire future research that could help potential targets of risk factor stratifications as well as the development of novel pharmacological options.
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