期刊
GELS
卷 8, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/gels8050261
关键词
hydrogel; chondroitin sulfate; endothelial cell; angiogenesis
资金
- International Science and Technology Cooperation Program of China [2015DFA30550]
- Key Science and Technology Project for Institutions of Higher Education of Henan Province [20B430019]
This study designed gelatin-based hydrogels loaded with chondroitin sulfate (CS) to regulate the angiogenesis behaviors of endothelial cells (ECs). The hydrogels exhibited excellent biocompatibility and hemocompatibility, and significantly promoted ECs angiogenesis behaviors. However, excessive loading of CS weakened the effect.
Functional hydrogels with properties that mimic the structure of extracellular matrix (ECM) and regulate cell behaviors have drawn much attention in biomedical applications. Herein, gelatin-based hydrogels were designed and loaded with chondroitin sulfate (CS) to endow biological regulation on the angiogenesis behaviors of endothelial cells (ECs). Manufactured hydrogels containing various amounts of CS were characterized via methods including mechanical tests, cytocompatibility, hemolysis, and angiogenesis assays. The results showed that the prepared hydrogels exhibited excellent mechanical stability, cytocompatibility, and hemocompatibility. Additionally, the angiogenesis behaviors of ECs were obviously promoted. However, excessive loading of CS would weaken the effect due to a higher proportion of occupation on the cell membrane. In conclusion, this investigation highlights the great potential of these hydrogels in treating ischemic diseases and accelerating tissue regeneration in terms of regulating the angiogenesis process via CS release.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据