3.8 Article

Disentangling tau and brain atrophy cluster heterogeneity across the Alzheimer's disease continuum

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

The Brain Chart of Aging: Machine-learning analytics reveals links between brain aging, white matter disease, amyloid burden, and cognition in the iSTAGING consortium of 10,216 harmonized MR scans

Mohamad Habes et al.

Summary: The relationship between white matter hyperintensities and various factors such as brain aging, AD neuropathology, cognitive decline, and Aβ positivity after age 65 have been observed in a large MRI database. The Brain Chart established can quantify brain-aging trajectories and provide systematic evaluation of brain-aging patterns relative to a large consortium. Brain aging, AD-like atrophy, and WMHs were shown to be better predictors of cognition than chronological age in MCI/AD subjects.

ALZHEIMERS & DEMENTIA (2021)

Review Medicine, General & Internal

Alzheimer's disease

Philip Scheltens et al.

Summary: Alzheimer's disease is projected to see a significant increase in prevalence in the future, with genetics playing a key role. Novel biomarkers and lifestyle-based prevention trials show promising therapeutic potential. Promising pharmacological treatments are advancing in clinical trials, targeting amyloid beta, tau, and inflammation.

LANCET (2021)

Article Biochemistry & Molecular Biology

Four distinct trajectories of tau deposition identified in Alzheimer's disease

Jacob W. Vogel et al.

Summary: By using an unbiased subtyping algorithm, the study systematically characterized longitudinal tau variability in human Alzheimer's disease, identifying four trajectories of tau deposition with distinct clinical features. The results suggest that variation in tau pathology is common and systematic, potentially necessitating a re-examination of the notion of 'typical AD' and a revisiting of tau pathological staging.

NATURE MEDICINE (2021)

Article Geriatrics & Gerontology

Cerebrovascular disease, neurodegeneration, and clinical phenotype in dementia with Lewy bodies

Daniel Ferreira et al.

Summary: The study found that cerebrovascular disease is associated with gray matter neurodegeneration in DLB patients, which may have implications for the treatment of DLB.

NEUROBIOLOGY OF AGING (2021)

Article Clinical Neurology

Accuracy of Tau Positron Emission Tomography as a Prognostic Marker in Preclinical and Prodromal Alzheimer Disease A Head-to-Head Comparison Against Amyloid Positron Emission Tomography and Magnetic Resonance Imaging

Rik Ossenkoppele et al.

Summary: This study demonstrates the prognostic accuracy of tau PET in predicting cognitive changes, which is superior to MRI and amyloid PET markers, supporting the prognostic process in early stages of Alzheimer's disease.

JAMA NEUROLOGY (2021)

Article Clinical Neurology

Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease

Rik Ossenkoppele et al.

ALZHEIMERS & DEMENTIA (2020)

Review Clinical Neurology

Biological subtypes of Alzheimer disease A systematic review and meta-analysis

Daniel Ferreira et al.

NEUROLOGY (2020)

Article Engineering, Biomedical

Robust Collaborative Clustering of Subjects and Radiomic Features for Cancer Prognosis

Hangfan Liu et al.

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING (2020)

Review Clinical Neurology

Whitepaper: Defining and investigating cognitive reserve, brain reserve, and brain maintenance

Yaakov Stern et al.

ALZHEIMERS & DEMENTIA (2020)

Article Cell Biology

Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain

Atsushi Aoyagi et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Article Clinical Neurology

Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies

Patricia A. Boyle et al.

ANNALS OF NEUROLOGY (2019)

Article Clinical Neurology

Person-Specific Contribution of Neuropathologies to Cognitive Loss in Old Age

Patricia A. Boyle et al.

ANNALS OF NEUROLOGY (2018)

Article Multidisciplinary Sciences

Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

Alexandra L. Young et al.

NATURE COMMUNICATIONS (2018)

Review Neurosciences

Tau PET imaging: present and future directions

Laure Saint-Aubert et al.

MOLECULAR NEURODEGENERATION (2017)

Article Clinical Neurology

Consensus classification of posterior cortical atrophy

Sebastian J. Crutch et al.

ALZHEIMERS & DEMENTIA (2017)

Article Clinical Neurology

TDP-43 is a key player in the clinical features associated with Alzheimer's disease

Keith A. Josephs et al.

ACTA NEUROPATHOLOGICA (2014)

Article Neurosciences

Clinical and multimodal biomarker correlates of ADNI neuropathological findings

Jon B. Toledo et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2013)

Article Mathematical & Computational Biology

The non-negative matrix factorization toolbox for biological data mining

Yifeng Li et al.

SOURCE CODE FOR BIOLOGY AND MEDICINE (2013)

Article Clinical Neurology

Amyloid deposition, hypometabolism, and longitudinal cognitive decline

Susan M. Landau et al.

ANNALS OF NEUROLOGY (2012)

Review Clinical Neurology

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

Peter T. Nelson et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2012)

Review Clinical Neurology

Posterior cortical atrophy

Sebastian J. Crutch et al.

LANCET NEUROLOGY (2012)

Article Geriatrics & Gerontology

MRI predictors of cognitive change in a diverse and carefully characterized elderly population

Owen Carmichael et al.

NEUROBIOLOGY OF AGING (2012)

Article Clinical Neurology

Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI

Leslie M. Shaw et al.

ACTA NEUROPATHOLOGICA (2011)

Review Clinical Neurology

Classification of primary progressive aphasia and its variants

M. L. Gorno-Tempini et al.

NEUROLOGY (2011)

Review Clinical Neurology

Clinical core of the Alzheimer's disease neuroimaging initiative: Progress and plans

Paul S. Aisen et al.

ALZHEIMERS & DEMENTIA (2010)

Article Clinical Neurology

Cerebrospinal Fluid Biomarker Signature in Alzheimer's Disease Neuroimaging Initiative Subjects

Leslie M. Shaw et al.

ANNALS OF NEUROLOGY (2009)

Article Clinical Neurology

Relationships between biomarkers in aging and dementia

W. J. Jagust et al.

NEUROLOGY (2009)

Article Psychiatry

Role of genes and environments for explaining Alzheimer disease

M Gatz et al.

ARCHIVES OF GENERAL PSYCHIATRY (2006)