期刊
MAGNETIC RESONANCE IN MEDICAL SCIENCES
卷 21, 期 1, 页码 168-181出版社
JPN SOC MAGNETIC RESONANCE MEDICINE
DOI: 10.2463/mrms.rev.2021-0031
关键词
magnetic resonance; liver; hepatocellular carcinoma; gadoxetic acid; xetate disodium; trast agents (e; g; Gadopentetate dimeglumine; Gadolinium
Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid is a hepatocyte-specific MR contrast agent that helps improve the detection and characterization of hepatocellular carcinoma. It can accurately detect both hypervascular and hypovascular HCC, and can also be used for liver function and prognostic evaluation.
Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA; Gadoxetic acid; Gadoxetate disodium) is a hepatocyte-specific MR contrast agent. It acts as an extracellular contrast agent in the early phase after intravenous injection, and then is taken up by hepatocytes later. Using this contrast agent, we can evaluate the hemodynamics of the liver and liver tumors, and can therefore improve the detection and characterization of hepatocellular carcinoma (HCC). Gd-EOB-DTPA helps in the more accurate detection of hypervascular HCC than by other agents. In addition, Gd-EOB-DTPA can detect hypovascular HCC, which is an early stage of the multi-stage carcinogenesis, with a low signal in the hepatobiliary phase. In addition to tumor detection and characterization, Gd-EOB-DTPA contrastenhanced MR imaging can be applied for liver function evaluation and prognoses evaluation. Thus, GdEOB-DTPA plays an important role in the diagnosis of HCC. However, we have to employ optimal imaging techniques to improve the diagnostic ability. In this review, we aimed to discuss the characteristics of the contrast media, optimal imaging techniques, diagnosis, and applications.
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