期刊
ARKIVOC
卷 -, 期 -, 页码 99-107出版社
ARKAT USA INC
DOI: 10.24820/ark.5550190.p011.685
关键词
Halloysite nanotubes; 3-oligotriazole; covalent modification; Huisgen reaction; HNTs-prodrug
资金
- University of Palermo
The development of nano-formulations for cancer treatment is a major challenge in scientific research. Using the prodrug strategy with nanocarriers can improve the biological activity of drug molecules and reduce their side effects.
In the last years, the development of nano-formulations for cancer treatment represents one of the major challenges of the scientific research. The prodrug strategy, that combines chemotherapeutic agents with nanocarriers such as halloysite nanotubes (HNTs), is a promising strategy both to improve the biological activity of the drug molecules and to reduce the side effects of drugs. Herein we report the synthesis and characterization of a HNTs prodrug based on 1,2,3-triazole units covalently linked to HNTs external surface, bearing different positively charged moieties, which could present interesting pharmacological activities.
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