4.7 Article

Nano Matrix Soft Confectionary for Oral Supplementation of Vitamin D: Stability and Sensory Analysis

期刊

GELS
卷 8, 期 5, 页码 -

出版社

MDPI
DOI: 10.3390/gels8050250

关键词

vitamin D; nanoemulsion; gelled matrices; texture analysis; gelatin; sensory evaluation; gummy

资金

  1. Taif University, Taif, Saudi Arabia [TURSP-2020/50]
  2. Jamia Hamdard Silver Jubilee Research Fellowship
  3. Jamia Hamdard, New Delhi

向作者/读者索取更多资源

Vitamin D deficiency is prevalent among nearly 50% of the global population, and this study developed a vitamin D oil-in-water nanoemulsion incorporated in edible gummies to enhance bioavailability and stability. The nanoemulsion prevented degradation of vitamin D and retained its activity over 15 days. The vitamin D gummies formulated with the nanoemulsion had optimal hardness and maintained taste and acceptance over 45 days of storage. This study highlights the potential of nanoemulsions to improve the delivery and effectiveness of vitamin D.
Vitamin D deficiency distresses nearly 50% of the population globally and multiple studies have highlighted the association of Vitamin D with a number of clinical manifestations, including musculoskeletal, cardiovascular, cerebrovascular, and neurological disorders. In the current study, vitamin D oil-in-water (O/W) nanoemulsions were developed and incorporated in edible gummies to enhance bioavailability, stability, and patient compliance. The spontaneous emulsification method was employed to produce a nano-emulsion using corn oil with tween 20 and lecithin as emulsifiers. Optimization was carried out using pseudo-ternary phase diagrams and the average particle size and polydispersity index (PDI) of the optimized nanoemulsion were found to be 118.6 +/- 4.3 nm and 0.11 +/- 0.30, respectively. HPLC stability analysis demonstrated that the nano-emulsion prevented the degradation and it retained more than 97% of active vitamin D over 15 days compared to 94.5% in oil solution. Similar results were obtained over further storage analysis. Vitamin D gummies based on emulsion-based gelled matrices were then developed using gelatin as hydrocolloid and varying quantities of corn oil. Texture analysis revealed that gummies formulated with 10% corn oil had the optimum hardness of 3095.6 +/- 201.7 g on the first day which remained consistent on day 45 with similar values of 3594.4 +/- 210.6 g. Sensory evaluation by 19 judges using the nine-point hedonic scale highlighted that the taste and overall acceptance of formulated gummies did not change significantly (p > 0.05) over 45 days storage. This study suggested that nanoemulsions consistently prevent the environmental degradation of vitamin D, already known to offer protection in GI by providing sustained intestinal release and enhancing overall bioavailability. Soft chewable matrices were easy to chew and swallow, and they provided greater patient compliance.

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