期刊
ANALYST
卷 147, 期 12, 页码 2773-2778出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2an00369d
关键词
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资金
- National Key Research and Development Program of China [2019YFC1605901]
- National Nature Science Foundation of China [21922403, 21874034]
- Fundamental Research Funds for the Central Universities [JZ2020HGQA0153]
The study successfully fabricated a nanocomplex based on gold nanoclusters with promising applications in bioimaging and biosensing. It demonstrates good ratiometric fluorescence sensing capability and biological imaging ability, along with high stability and excellent biocompatibility.
Gold nanoclusters (Au NCs) have become a new alternative to conventional fluorescent probes in biosensing and imaging. Herein, a gold nanocluster-based nanocomplex displaying single-excitation and dual-emission fluorescence property was fabricated by the conjugation of red-emitting glutathione-protected gold nanoclusters (Au-GSH NCs) and green-emitting fluorescein isothiocyanate (FITC) molecules. The inorganic-organic nanocomplex possesses good ratiometric fluorescence sensing ability with one emission peak showing a sensitive fluorescence response towards Hg2+ ions and the other acting as the internal reference. The nanocomplex was demonstrated to have high stability, excellent biocompatibility, high intracellular penetrability and good biological imaging ability. It was employed as a sensitive nanosensor for rapid sensing and imaging of Hg2+ ions in living cells and zebrafish with high contrast.
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