Severe Multisystem Inflammatory Symptoms in 2 Adults after Short Interval between COVID-19 and Subsequent Vaccination

We observed multisystem inflammatory syndrome in 2 older adults in the United States who had received mRNA coronavirus disease vaccine soon after natural infection. We identified 5 similar cases from the Vaccine Adverse Events Reporting System. The timing of vaccination soon after natural infection might have an adverse effect on the occurrence of vaccine-related systemic inflammatory disorders.

Automated summary

This study observed the occurrence of multisystem inflammatory syndrome in 2 older adults in the United States who received mRNA coronavirus vaccine soon after natural infection. 5 similar cases were identified from the Vaccine Adverse Events Reporting System. The timing of vaccination after natural infection may have an adverse effect on the development of vaccine-related systemic inflammatory disorders.