期刊
EMERGING INFECTIOUS DISEASES
卷 28, 期 5, 页码 915-923出版社
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2805.211497
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This article describes 10 outbreaks associated with home healthcare in England during 2018-2019. These outbreaks resulted in 96 cases of infection and 28 deaths, with varying durations and intervals between cases. The identification and control of these outbreaks required multiple interventions, and the transmission routes and effective interventions are still unclear.
Healthcare-associated invasive group A Streptococcus (iGAS) outbreaks are common worldwide, but only England has reported outbreaks associated with home healthcare (HHC). We describe 10 outbreaks during 2018-2019 in England. A total of 96 iGAS cases (range 2-39 per outbreak) and 28 deaths (case-fatality rate 29%) occurred. Outbreak duration ranged from 3-517 days; median time between sequential cases was 20.5 days (range 1-225 days). Outbreak identification was difficult, but emm typing and whole-genome sequencing improved detection. Network analyses indicated multiple potential transmission routes. Screening of 366 HHC workers from 9 outbreaks identified group A Streptococcus carriage in just 1 worker. Outbreak control required multiple interventions, including improved infection control, equipment decontamination, and antimicrobial prophylaxis for staff. Transmission routes and effective interventions are not yet clear, and iGAS outbreaks likely are underrecognized. To improve patient safety and reduce deaths, public health agencies should be aware of HHC-associated iGAS.
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