期刊
GELS
卷 8, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/gels8050306
关键词
hydrogels; antibacterial agents; infection control; bone repair
资金
- National Natural Science Foundation [82071108, 32171354]
- Fundamental Research Funds for Central Universities
- Project of Science and Technology Department of Sichuan Province [2021YJ0228]
- Science and Technology Application Demonstration Projects in Chengdu [2021-YF09-00078-SN]
- Research and Develop Program, West China Hospital of Stomatology Sichuan University [LCYJ2020-YJ-3]
This review summarizes the recent progress in incorporating different types of antibacterial agents into hydrogels and discusses the advantages and disadvantages of antibacterial agent hybrid hydrogels. It provides valuable insights and prospects for the treatment of infected bone defects.
The repair of infected bone defects (IBDs) is still a great challenge in clinic. A successful treatment for IBDs should simultaneously resolve both infection control and bone defect repair. Hydrogels are water-swollen hydrophilic materials that maintain a distinct three-dimensional structure, helping load various antibacterial drugs and biomolecules. Hybrid hydrogels may potentially possess antibacterial ability and osteogenic activity. This review summarizes the recent progress of different kinds of antibacterial agents (including inorganic, organic, and natural) encapsulated in hydrogels. Several representative hydrogels of each category and their antibacterial mechanism and effect on bone repair are presented. Moreover, the advantages and disadvantages of antibacterial agent hybrid hydrogels are discussed. The challenge and future research directions are further prospected.
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