Cow's milk αS1-casein is more sensitizing than goat's milk αS1-casein in a mouse model

The aim of this study was to compare the sensitization of alpha(S1)-CN in cow and goat's milk in a mouse model. Fifty mice were divided into control group, adjuvant control group, cow's milk alpha(S1)-CN sensitized group, goat's milk alpha(S1)-CN sensitized group and cross sensitized group. Cow's and goat's milk alpha(S1)-CN were used to establish a mouse sensitization model. The results showed that cow's milk alpha(S1)-CN had higher allergenicity than goat's milk alpha(S1)-CN, as can be seen in significantly increased s-IgE and Th2 cell-related inflammatory factors, the proportion of Th2, and the expression of Th2 cell-related transcription factors. Furthermore, the sensitization of cow's milk alpha(S1)-CN damaged the intestinal barrier of mice, caused the leakage of LPS, activated the TLR4-NF kappa B pathway, and thus resulted in the increase of IFN-gamma. In addition, mice allergic to cow's milk alpha(S1)-CN were less sensitized to goat's milk alpha(S1)-CN.

Automated summary

This study aimed to compare the sensitization of alpha(S1)-CN in cow and goat's milk in a mouse model. The results showed that cow's milk alpha(S1)-CN had higher allergenicity than goat's milk alpha(S1)-CN and the sensitization of cow's milk alpha(S1)-CN damaged the intestinal barrier of mice and resulted in an increase of IFN-gamma. Additionally, mice allergic to cow's milk alpha(S1)-CN were less sensitized to goat's milk alpha(S1)-CN.