Early and progressive dysfunction revealed by in vivo neurite imaging in the rNLS8 TDP-43 mouse model of ALS

Article Neurosciences

miR-23a suppression accelerates functional decline in the rNLS8 mouse model of TDP-43 proteinopathy

Stavroula Tsitkanou et al.

Summary: Skeletal muscle dysfunction may contribute to the progression and severity of ALS. In an ALS mouse model, suppression of miR-23a accelerates disease progression.

NEUROBIOLOGY OF DISEASE (2022)

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Review Neurosciences

Modelling amyotrophic lateral sclerosis in rodents

Tiffany W. Todd et al.

Summary: Efficient study of human disease requires accurate animal models. For amyotrophic lateral sclerosis (ALS), animal models based on genetic mutations identified in familial cases have been developed. The increase in the number of ALS-associated genes has driven the development of more animal models. Rodent models are particularly important as they allow for the study of ALS in the context of a living mammal with a comparable CNS. These models help verify the pathogenicity of novel mutations and provide insights into disease mechanisms, as well as testing new therapeutics.

NATURE REVIEWS NEUROSCIENCE (2022)

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Article Neurosciences

Impaired glymphatic function in the early stages of disease in a TDP-43 mouse model of amyotrophic lateral sclerosis

Akram Zamani et al.

Summary: This study found that the glymphatic system is impaired in the early stages of amyotrophic lateral sclerosis (ALS), leading to progressive neurodegeneration and disrupted glymphatic function. This suggests that the glymphatic system could be a potential therapeutic target for ALS treatment.

TRANSLATIONAL NEURODEGENERATION (2022)

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Article Critical Care Medicine

White Matter Abnormalities in Retired Professional Rugby League Players with a History of Concussion

David K. Wright et al.

Summary: This study examined the white matter microstructure differences between retired professional Australian National Rugby League (NRL) players with a history of multiple concussions and age- and education-matched controls with no history of brain trauma. The NRL players scored significantly higher on the alcohol use disorder identification test (AUDIT), and the diffusion tensor imaging (DTI) revealed significant differences in white matter regions of NRL players compared to controls. The findings suggest potential long-term neurological consequences of multiple concussions in collision sports.

JOURNAL OF NEUROTRAUMA (2021)

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Article Neuroimaging

White matter changes following experimental pediatric traumatic brain injury: an advanced diffusion-weighted imaging investigation

Akram Zamani et al.

Summary: The study utilizes advanced DWI techniques to assess white matter changes following pediatric traumatic brain injury (pTBI), revealing significant reductions in fiber density and TWI metrics in the white matter of injured mice compared to controls.

BRAIN IMAGING AND BEHAVIOR (2021)

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Article Neurosciences

Diffusion Imaging Reveals Sex Differences in the White Matter Following Sports-Related Concussion

David K. Wright et al.

Summary: The preliminary study showed that male athletes with SRC reported more severe symptoms compared to female athletes. dMRI revealed white matter differences between SRC athletes and non-concussed athletes at 48 hours post-injury, which persisted at 2 weeks post-injury. Furthermore, male SRC athletes exhibited significantly greater white matter disruption than female SRC athletes. These findings have implications for concussion management, including return-to-play decisions, and enhance our understanding of the role of sex in SRC outcomes.

CEREBRAL CORTEX (2021)

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Review Biochemistry & Molecular Biology

Diffusion Magnetic Resonance Imaging-Based Biomarkers for Neurodegenerative Diseases

Koji Kamagata et al.

Summary: With the rapid increase in aging societies worldwide, there has been a growing prevalence of neurodegenerative diseases, highlighting the urgent need for biomarkers to enable early intervention. Diffusion MRI is a promising tool for inferring microstructural characteristics of the brain, and new technologies are being developed to overcome the limitations of diffusion tensor imaging.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Neurosciences

Riluzole does not ameliorate disease caused by cytoplasmic TDP-43 in a mouse model of amyotrophic lateral sclerosis

Amanda L. Wright et al.

Summary: Riluzole did not have a positive effect on disease-related phenotypes in female transgenic mice closely recapitulating TDP-43 pathology, suggesting the need to target pathways related to TDP-43 accumulation for developing better ALS treatments in the future.

EUROPEAN JOURNAL OF NEUROSCIENCE (2021)

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Review Clinical Neurology

Advanced neuroimaging approaches in amyotrophic lateral sclerosis: refining the clinical diagnosis

Jan Kassubek et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2020)

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Review Clinical Neurology

Time to diagnosis and factors affecting diagnostic delay in amyotrophic lateral sclerosis

Danielle Richards et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2020)

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Review Biochemical Research Methods

NODDI in clinical research

Kouhei Kamiya et al.

JOURNAL OF NEUROSCIENCE METHODS (2020)

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Article Clinical Neurology

Unveiling early cortical and subcortical neuronal degeneration in ALS mice by ultra-high field diffusion MRI

Rodolfo G. Gatto et al.

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2019)

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Article Neurosciences

Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43G298S ALS mouse model

Hans-Peter Mueller et al.

TRANSLATIONAL NEURODEGENERATION (2019)

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Article Neurosciences

Neurite orientation dispersion and density imaging reveals white matter and hippocampal microstructure changes produced by Interleukin-6 in the TgCRND8 mouse model of amyloidosis

Luis M. Colon-Perez et al.

NEUROIMAGE (2019)

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Review Neurosciences

MRtrix3: A fast, flexible and open software framework for medical image processing and visualisation

J-Donald Tournier et al.

NEUROIMAGE (2019)

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Article Clinical Neurology

Neurite orientation and dispersion density imaging (NODDI) detects cortical and corticospinal tract degeneration in ALS

Rebecca J. Broad et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2019)

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Article Clinical Neurology

Neurite density is reduced in the presymptomatic phase of C9orf72 disease

Junhao Wen et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2019)

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Article Cell Biology

Mutant TDP-43 Causes Early-Stage Dose-Dependent Motor Neuron Degeneration in a TARDBP Knockin Mouse Model of ALS

Sarah Y. Ebstein et al.

CELL REPORTS (2019)

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Article Clinical Neurology

Predictors of diagnostic delay in amyotrophic lateral sclerosis: a cohort study based on administrative and electronic medical records data

Francesca Palese et al.

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2019)

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Article Critical Care Medicine

Changes in Apparent Fiber Density and Track-Weighted Imaging Metrics in White Matter following Experimental Traumatic Brain Injury

David K. Wright et al.

JOURNAL OF NEUROTRAUMA (2017)

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Article Geriatrics & Gerontology

ApoE influences regional white-matter axonal density loss in Alzheimer's disease

Catherine F. Slattery et al.

NEUROBIOLOGY OF AGING (2017)

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Article Clinical Neurology

A large-scale multicentre cerebral diffusion tensor imaging study in amyotrophic lateral sclerosis

Hans-Peter Mueller et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2016)

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Article Neurosciences

An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging

Jesper L. R. Andersson et al.

NEUROIMAGE (2016)

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Article Neurosciences

Application of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease

N. Colgan et al.

NEUROIMAGE (2016)

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Article Neuroimaging

Structural and diffusion imaging versus clinical assessment to monitor amyotrophic lateral sclerosis

Arturo Cardenas-Blanco et al.

NEUROIMAGE-CLINICAL (2016)

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Article Clinical Neurology

Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43

Adam K. Walker et al.

ACTA NEUROPATHOLOGICA (2015)

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Review Clinical Neurology

Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2

Clifford R. Jack et al.

ALZHEIMERS & DEMENTIA (2015)

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Article Neurosciences

Connectivity-based fixel enhancement: Whole-brain statistical analysis of diffusion MRI measures in the presence of crossing fibres

David A. Raffelt et al.

NEUROIMAGE (2015)

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Review Clinical Neurology

Neuroimaging in amyotrophic lateral sclerosis: insights into structural and functional changes

Adriano Chio et al.

LANCET NEUROLOGY (2014)

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Article Neuroimaging

Evaluation of multi-modal, multi-site neuroimaging measures in Huntington's disease: Baseline results from the PADDINGTON study

Nicola Z. Hobbs et al.

NEUROIMAGE-CLINICAL (2013)

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Article Neurosciences

Apparent Fibre Density: A novel measure for the analysis of diffusion-weighted magnetic resonance images

David Raffelt et al.

NEUROIMAGE (2012)

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Article Neurosciences

NODDI: Practical in vivo neurite orientation dispersion and density imaging of the human brain

Hui Zhang et al.

NEUROIMAGE (2012)

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Article Clinical Neurology

The contribution of gliosis to diffusion tensor anisotropy and tractography following traumatic brain injury: validation in the rat using Fourier analysis of stained tissue sections

Matthew D. Budde et al.

BRAIN (2011)

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Article Medicine, General & Internal

Amyotrophic lateral sclerosis

Matthew C. Kiernan et al.

LANCET (2011)

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Article Neurosciences

Non-invasive diffusion tensor imaging detects white matter degeneration in the spinal cord of a mouse model of amyotrophic lateral sclerosis

Clare K. Underwood et al.

NEUROIMAGE (2011)

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Article Neurosciences

Threshold-free cluster enhancement: Addressing problems of smoothing, threshold dependence and localisation in cluster inference

Stephen M. Smith et al.

NEUROIMAGE (2009)

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Article Neurosciences

Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data

Stephen M. Smith et al.

NEUROIMAGE (2006)

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Article Clinical Neurology

Diffusion tensor MRI of early upper motor neuron involvement in amyotrophic lateral sclerosis

M Sach et al.

BRAIN (2004)

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Article Clinical Neurology

El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis

BR Brooks et al.

AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS (2000)

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Early and progressive dysfunction revealed by in vivo neurite imaging in the rNLS8 TDP-43 mouse model of ALS

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