4.6 Review

Rational construction of polycystine-based nanoparticles for biomedical applications

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Review Polymer Science

A Guideline for the Synthesis of Amino-Acid-Functionalized Monomers and Their Polymerizations

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Summary: Amino acids are considered a sustainable source for the design of functional polymers due to their wide availability and high biocompatibility. Their reactive functional groups make them suitable for various polymerization approaches. This review focuses on strategies to incorporate amino acids into polymers, including the preparation of polymerizable monomers and postpolymerization modification approaches for polymer side chain functionalization. Amino acids are presented as a versatile platform for developing polymers with tailored properties.

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Intravesical delivery of KDM6A-mRNA via mucoadhesive nanoparticles inhibits the metastasis of bladder cancer

Na Kong et al.

Summary: A mucoadhesive messenger RNA nanoparticle strategy was used for intravesical delivery of KDM6A-mRNA in mice with orthotopic Kdm6a-null BCa, demonstrating KDM6A's therapeutic potential in inhibiting BCa metastasis.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Article Multidisciplinary Sciences

Polypeptide nanoformulation-induced immunogenic cell death and remission of immunosuppression for enhanced chemoimmunotherapy

Xiangru Feng et al.

Summary: Conventional chemotherapeutics induce immunogenic cell death in tumor cells, but are limited by the presence of immunosuppressive lymphocytes in the tumor microenvironment. Combining low-dose DOX with 1MT to overcome immune suppression, delivered via a reduction-responsive polypeptide nanogel, effectively suppressed tumor growth and enhanced CD8(+) T cell frequency. The chemoimmunotherapy strategy shows great potential in clinical cancer therapy.

SCIENCE BULLETIN (2021)

Article Chemistry, Multidisciplinary

Cystine proportion regulates fate of polypeptide nanogel as nanocarrier for chemotherapeutics

Xiangru Feng et al.

Summary: The physicochemical characteristics of nanoparticles play a crucial role in determining their drug delivery performance, and altering the amino acid composition can adjust the drug release profile and antitumor efficacy of nanogels.

SCIENCE CHINA-CHEMISTRY (2021)

Review Physics, Applied

Smart transformable nanoparticles for enhanced tumor theranostics

Jinjin Chen et al.

Summary: The physical morphologies of nanoparticles significantly influence their biological behaviors, and smart transformable nanomaterials show great potential in advanced tumor theranostics.

APPLIED PHYSICS REVIEWS (2021)

Article Polymer Science

Preparation of Synthetic Polypeptide-PolyHIPE Hydrogels with Stimuli-Responsive Behavior

Ozgun Can Onder et al.

Summary: In this study, biodegradable macroporous stimuli-responsive polypeptide hydrogels based on L-glutamic acid and its copolymers were prepared and their pH-dependent behavior and mechanical properties were investigated. By tuning the chemical composition of the polypeptides, the uptake, enzymatic degradation, and compression behavior of the hydrogels can be modulated.

MACROMOLECULES (2021)

Article Materials Science, Multidisciplinary

Glucose-responsive oral insulin delivery platform for one treatment a day in diabetes

Yufen Xiao et al.

Summary: An intelligent oral insulin platform has been developed using glucose-responsive polymeric nanoparticles to protect insulin integrity, overcome intestinal barriers, and release insulin based on blood glucose levels. This platform provides extended therapeutic effects and may reduce insulin administration frequency.

MATTER (2021)

Review Biochemistry & Molecular Biology

Strategies To Design and Synthesize Polymer-Based Stimuli-Responsive Drug-Delivery Nanosystems

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CHEMBIOCHEM (2020)

Review Chemistry, Multidisciplinary

Advances in aggregatable nanoparticles for tumor-targeted drug delivery

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CHINESE CHEMICAL LETTERS (2020)

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Controlled synthesis of polypeptides

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CHINESE CHEMICAL LETTERS (2020)

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A map of the amine-carboxylic acid coupling system

Babak Mahjour et al.

NATURE (2020)

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Biomimetic chitosan-graft-polypeptides for improved adhesion in tissue and metal

Dedai Lu et al.

CARBOHYDRATE POLYMERS (2019)

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Engineered nanomedicines with enhanced tumor penetration

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NANO TODAY (2019)

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pHe- and glutathione-stepwise-responsive polypeptide nanogel for smart and efficient drug delivery

Titao Jing et al.

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Imaging-Guided pHe and Glutathione Dual Responsive Polypeptide Nanogel for Smart Drug Delivery

Titao Jing et al.

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Reduction-sensitive polypeptide nanogel conjugated BODIPY-Br for NIR imaging-guided them/photodynamic therapy at low light and drug dose

Le Liu et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

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Influence of Sulfur-Containing Diamino Acid Structure on Covalently Crosslinked Copolypeptide Hydrogels

Eric D. Raftery et al.

CHEMISTRY-AN ASIAN JOURNAL (2018)

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Reduction-Responsive Polypeptide Nanogel for Intracellular Drug Delivery in Relieving Collagen-Induced Arthritis

Naibo Feng et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

Review Chemistry, Physical

Advances in Stimuli-Responsive Polypeptide Nanogels

Zhongyu Jiang et al.

SMALL METHODS (2018)

Article Chemistry, Multidisciplinary

Sequentially Responsive Shell-Stacked Nanoparticles for Deep Penetration into Solid Tumors

Jinjin Chen et al.

ADVANCED MATERIALS (2017)

Article Polymer Science

Preparation of Hybrid Triple-Stimuli Responsive Nanogels Based on Poly(L-histidine)

Panayiotis Bilalis et al.

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY (2016)

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Dual-responsive star-shaped polypeptides for drug delivery

Wenlong Wang et al.

RSC ADVANCES (2016)

Review Chemistry, Multidisciplinary

PEG - A versatile conjugating ligand for drugs and drug delivery systems

Atul Kolate et al.

JOURNAL OF CONTROLLED RELEASE (2014)

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Design of polymeric nanoparticles for biomedical delivery applications

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Development of functional amino acid-based star polymers

Adrian Sulistio et al.

POLYMER CHEMISTRY (2012)

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Folic Acid Conjugated Amino Acid-Based Star Polymers for Active Targeting of Cancer Cells

Adrian Sulistio et al.

BIOMACROMOLECULES (2011)

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Hexamethyldisilazane-mediated controlled polymerization of α-Amino acid N-carboxyanhydrides

Hua Lu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)