期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 10, 期 37, 页码 7173-7182出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2tb00581f
关键词
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资金
- National Natural Science Foundation of China [52022095, 52073280, 51973216, 51873207, 51833010]
- Science and Technology Development Program of Jilin Province [20210509005RQ, 20200404182YY]
- Youth Innovation Promotion Association of Chinese Academy of Sciences [2019230]
- Program of Guangdong Science and Technology Department [2020B1212030004, 2020B1212060018]
This review summarizes the development of Cys(2)-based polypeptide nanoparticles and their unique properties and multifunctional applications.
Polypeptide-based nanoparticles are one of the promising excipients of nanomedicines due to their excellent biosafety and flexible modification. Among all the types of polypeptide nanoparticles, polycystine (PCys(2))-based ones draw increasing attention due to their unique properties. On the one hand, the uniformed nanogels can be easily obtained through the crosslinking of two active centers during polymerization without additional step of self-assembly. On the other hand, the Cys(2)-based nanoparticles always showed reduction-responsiveness owing to the inherent disulfide bond. With the development of advanced diagnostic and therapeutic technologies, the multi-functional PCys(2)-based nanoparticles were achieved via rational construction of the polymer structure. This review summarizes the overall development of Cys(2)-based polypeptide nanoparticles, especially the structural design for the generation of multi-functional nanoparticles, along with their corresponding biomedical applications.
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