The Relationship Between 5-Hydroxytryptamine and Its Metabolite Changes With Post-stroke Depression

Post-stroke depression (PSD) is the most common and serious sequelae of stroke. Approximately 33% of stroke survivors were affected by PSD. However, many issues (e.g., incidence, diagnostic marker, and risk factor) related to PSD remained unclear. The monoamine hypothesis is a significant hypothesis for depression, which suggests that three monoamines play a key role in depression. Therefore, most current antidepressants are developed to modulate the monoamines on PSD treatment, and these antidepressants have good effects on patients with PSD. However, the potential mechanisms of three monoamines in PSD are still unclear. Previously, we proposed three primary emotions, which suggested a new model of basic emotions based on the three monoamines. It may provide a new way for PSD treatment. In addition, recent studies have found that monoamine-related emotional intervention also showed potential effects in the treatment and prevention of PSD. This study discusses these issues and attempts to provide a prospect for future research on PSD.

Automated summary

Post-stroke depression is a common and serious consequence of stroke, but many aspects related to it are still unclear. The monoamine hypothesis suggests that three monoamines play a key role in depression, and current antidepressants target these monoamines for the treatment of post-stroke depression. Recent studies have also shown potential effects of monoamine-related emotional intervention in the treatment and prevention of post-stroke depression.