☆ 4.7 Letter

A robust reporting system for measurement of SARS-CoV-2 spike fusion efficiency

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Mechanisms of SARS-CoV-2 entry into cells

Cody B. Jackson et al.

Summary: The entry of SARS-CoV-2 into host cells is facilitated by the interaction between the viral spike protein and ACE2, leading to virus-cell membrane fusion, which has been extensively studied at the structural and cellular levels worldwide. This understanding has paved the way for the development of effective vaccines in response to the COVID-19 pandemic, caused by the infection with SARS-CoV-2.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

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Letter Biochemistry & Molecular Biology

SARS-CoV-2 spike L452R mutation increases Omicron variant fusogenicity and infectivity as well as host glycolysis

Yanan Zhang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Review Virology

Single-Molecule FRET Imaging of Virus Spike-Host Interactions

Maolin Lu

Summary: The virus spike protein plays a crucial role in virus entry, and understanding its dynamic nature is essential. Single-molecule Forster resonance energy transfer (smFRET) technique has provided a powerful platform for revealing the dynamic process of virus spikes, contributing to research on the mechanism of virus entry.

VIRUSES-BASEL (2021)

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Article Multidisciplinary Sciences

Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia

Luca Braga et al.

Summary: COVID-19 patients' lungs contain infected pneumocytes with abnormal morphology and frequent multinucleation, leading to the formation of syncytia driven by the activation of the SARS-CoV-2 spike protein. The antihelminthic drug niclosamide has shown to effectively inhibit cell fusion, potentially providing a new therapeutic approach for COVID-19 disease pathogenesis.

NATURE (2021)

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Review Chemistry, Analytical

The β-Lactamase Assay: Harnessing a FRET Biosensor to Analyse Viral Fusion Mechanisms

Daniel M. Jones et al.

SENSORS (2016)

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A robust reporting system for measurement of SARS-CoV-2 spike fusion efficiency

相关参考文献

Mechanisms of SARS-CoV-2 entry into cells

SARS-CoV-2 spike L452R mutation increases Omicron variant fusogenicity and infectivity as well as host glycolysis

Single-Molecule FRET Imaging of Virus Spike-Host Interactions

Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia

The β-Lactamase Assay: Harnessing a FRET Biosensor to Analyse Viral Fusion Mechanisms

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