Microglia at the Crossroads of Pathogen-Induced Neuroinflammation

Microglia are the resident tissue macrophages of the central nervous system (CNS). Recent findings point out that in the steady state the major role of microglia, is to instruct and regulate the correct function of the neuronal networks and different components of the neurovascular unit in the adult CNS, while providing immune surveillance. Paradoxically, during CNS infection immune activation of microglia generates an inflammatory milieu that contributes to the clearance of the pathogen but can, in the process, harm nearby cells of CNS. Most of the knowledge about the harmful effects of activated microglia on CNS has arisen from studies on neurodegenerative diseases. In this review we will focus on the beneficial role and detrimental functions of microglial cells on the neighboring cells of the CNS upon infection.

Automated summary

Microglia play both beneficial and detrimental roles in the central nervous system (CNS). In the steady state, they regulate the function of neuronal networks and neurovascular units while providing immune surveillance. However, during CNS infection, immune activation of microglia can generate an inflammatory environment that contributes to pathogen clearance but also harms nearby cells of the CNS.