期刊
BIOMATERIALS SCIENCE
卷 10, 期 13, 页码 3433-3440出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2bm00101b
关键词
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资金
- National Key Research and Development Program of China [2020YFA0710302]
- Major Research Plan of the National Natural Science Foundation of China [91963206]
- National Natural Science Foundation of China [52072169, 51627810, 51972164, 51972167]
- Fundamental Research Funds for the Central Universities [14380193]
- Program for Guangdong Introducing Innovative and Entrepreneurial Teams [2019ZT08L101]
- Natural Science Foundation of Jiangsu Province [SBK2018022120]
- Open Fund of Wuhan National Laboratory for Optoelectronics [2018WNLOKF020]
- Civil Aerospace Technology Research Project [B0108]
- Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory
In this study, a high-energy radiation-based photocatalysis method called radiocatalysis was proposed, and a TiO2-coated lanthanide pyrosilicate scintillator (LnPS@TiO2) was prepared as the radiocatalytic material. This method can effectively kill cancer cells and cause long-term DNA damage. The research expands the application range of photocatalysis and has significant implications for tumor treatment.
Photocatalytic materials absorb photons ranging from the ultraviolet to near-infrared region to initiate photocatalytic reactions and have broad application prospects in various fields. However, high-energy ionizing radiations are rarely involved in photocatalytic research. In this study, we proposed a high-energy radiation-based photocatalysis method, namely radiocatalysis, and prepared a TiO2-coated lanthanide pyrosilicate scintillator (LnPS@TiO2) as the radiocatalytic material. The lanthanide pyrosilicate post-radiation scintillators can efficiently convert radiation energy into ultraviolet energy, which can be resonantly transferred to TiO2 to selectively generate high-yield superoxide radicals (O-2*(-)). Compared with traditional radiotherapy, this radiocatalytic process can significantly kill cancer cells while achieving longterm DNA damage by inhibiting the DNA self-repair process. Our research expands the energy response range of photocatalysis and is expected to extend radiocatalysis to the tumor treatment field.
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