期刊
ANIMAL NUTRITION
卷 9, 期 -, 页码 159-174出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.aninu.2021.09.012
关键词
Short chain fatty acids; Gut microbiota; Intestinal barrier; Intestinal epithelium cells; Interaction mechanism
资金
- National Natural Science Foundation of China [31772612]
- Beijing Natural Science Foundation [6202019]
The interaction between gut microbiota and the host gut is crucial for maintaining the homeostasis of the organism, with short chain fatty acids playing a vital role in regulating intestinal community homeostasis and influencing the host gut barriers.
The mammalian gut is inhabited by a massive and complicated microbial community, in which the host achieves a stable symbiotic environment through the interdependence, coordination, reciprocal constraints and participation in an immune response. The interaction between the host gut and the microbiota is essential for maintaining and achieving the homeostasis of the organism. Consequently, gut homeostasis is pivotal in safeguarding the growth and development and potential productive performance of the host. As metabolites of microorganisms, short chain fatty acids are not only the preferred energy metabolic feedstock for host intestinal epithelial cells, but also exert vital effects on antioxidants and the regulation of intestinal community homeostasis. Herein, we summarize the effects of intestinal microorganisms on the host gut and the mechanisms of action of short chain fatty acids on the four intestinal barriers of the organism, which will shed light on the manipulation of the intestinal community to achieve precise nutrition for specific individuals and provide a novel perspective for the prevention and treatment of diseases. ?? 2022 Chinese Association of Animal Science and Veterinary Medicine. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据