期刊
PROSTAGLANDINS & OTHER LIPID MEDIATORS
卷 161, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.prostaglins.2022.106639
关键词
Breast cancer; Lipid peroxidation; Oxidative stress; Prognosis
资金
- CAPES - Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
- CNPq - Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
- Fundacao Araucaria e Programa de Pesquisa para o SUS (PPSUS)
- FAPERJ - Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro
This study investigated the levels of lipid peroxidation (LPO) in tumor and plasma samples from breast cancer patients, and found that high LPO levels were associated with poor prognosis parameters.
Oxidative stress can promote the oxidation of lipoproteins and polyunsaturated fatty acids present in cell membranes; an event known as lipid peroxidation (LPO). LPO has been associated with carcinogenesis and cancer progression, however, its meaning concerning the clinicopathological aspects of human breast cancer is not clear. This study investigated LPO profiles in tumor and plasma samples from breast cancer patients (n = 140) considering their clinicopathological features (age at diagnosis, menopausal status, body mass index, tumor histological grade, tumor size, ki-67 proliferation index, presence of metastasis, chemotherapy response, the molecular subtype of cancer and overall survival status). LPO levels were estimated by tert-butyl hydroperoxideinitiated chemiluminescence. High LPO levels were found regarding poor prognosis parameters as young age at diagnosis (p = 0.006 in tissue), premenopausal patients (p = 0.012 in tissue), high-grade tumors (p = 0.010 in tissue and p = 0.002 in plasma), metastatic disease (p = 0.046 in tissue), chemoresistant tumors (p = 0.041 in tissue), disease relapse (p = 0.018 in tissue and p = 0.009 in plasma) and overall survival status (p = 0.001 in plasma). Our findings point out the clinical meaning of LPO and highlight it as an oxidative stress event linked to poor prognosis and disease aggressiveness in breast cancer patients.
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